ID   C7FEV1_THESA            Unreviewed;       495 AA.
AC   C7FEV1;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=HfsD {ECO:0000313|EMBL:ACU11597.1};
OS   Thermoanaerobacterium saccharolyticum.
OC   Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacteraceae; Thermoanaerobacterium.
OX   NCBI_TaxID=28896 {ECO:0000313|EMBL:ACU11597.1};
RN   [1] {ECO:0000313|EMBL:ACU11597.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19648238; DOI=10.1128/JB.00497-09;
RA   Shaw A.J., Hogsett D.A., Lynd L.R.;
RT   "Identification of the [FeFe]-hydrogenase responsible for hydrogen
RT   generation in Thermoanaerobacterium saccharolyticum and demonstration of
RT   increased ethanol yield via hydrogenase knockout.";
RL   J. Bacteriol. 191:6457-6464(2009).
RN   [2] {ECO:0000313|EMBL:ACU11597.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Shaw A.J.IV., Hogsett D.A., Lynd L.R.;
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GQ354412; ACU11597.1; -; Genomic_DNA.
DR   AlphaFoldDB; C7FEV1; -.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd10549; MtMvhB_like; 1.
DR   Gene3D; 3.30.70.20; -; 2.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR009016; Fe_hydrogenase.
DR   InterPro; IPR004108; Fe_hydrogenase_lsu_C.
DR   InterPro; IPR027631; Mono_FeFe_hydrog.
DR   NCBIfam; TIGR04105; FeFe_hydrog_B1; 1.
DR   PANTHER; PTHR11615:SF368; HYDROGENASE-RELATED; 1.
DR   PANTHER; PTHR11615; NITRATE, FORMATE, IRON DEHYDROGENASE; 1.
DR   Pfam; PF02906; Fe_hyd_lg_C; 1.
DR   Pfam; PF00037; Fer4; 2.
DR   SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR   SUPFAM; SSF53920; Fe-only hydrogenase; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 2.
DR   PROSITE; PS51379; 4FE4S_FER_2; 3.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          89..118
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          119..148
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          165..194
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
SQ   SEQUENCE   495 AA;  54490 MW;  81791087C1E5ADBE CRC64;
     MLKYEVLYNV AKLTLEDRLE DEYDEIPYEI IPGTKPRFRC CVYKERAIIE QRTKVAMGKN
     LKRTMKHAVD GEEPIIQVLD IACEECPIKR YRVTEACRGC ITHRCTEVCP KGAITIINKK
     ANIDYDKCIE CGRCKDACPY NAISDNLRPC IRSCSAKAIT MDEELKAAIN YEKCTSCGAC
     TLACPFGAIT DKSYIVDIIR AIKSGKKVYA LVAPAIASQF KDVTVGQIKS ALKEFGFVDV
     IEVALGADFV AMEEAKEFSH KIKDIKVMTS SCCPAFVAHI KKSYPELSQN ISTTVSPMTA
     ISKYIKKHDP MAVTVFIGPC TAKKSEVMRD DVKGITDFAM TFEEMVAVLD AAKIDMKEQQ
     DVEVDDATLF GRKFARSGGV LEAVVEAVKE IGADVEVNPV VCNGLDECNK TLKIMKAGKL
     PNNFIEGMAC IGGCIGGAGV INNNVNQAKL AVNKFGDSSY HKSIKDRISQ FDTDDVDFHV
     DSGEDESSET SFKEA
//