ID   C7GCD8_9FIRM            Unreviewed;       518 AA.
AC   C7GCD8;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Diguanylate cyclase (GGDEF) domain protein {ECO:0000313|EMBL:EEV00517.1};
GN   ORFNames=ROSINTL182_07574 {ECO:0000313|EMBL:EEV00517.1};
OS   Roseburia intestinalis L1-82.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=536231 {ECO:0000313|EMBL:EEV00517.1, ECO:0000313|Proteomes:UP000004828};
RN   [1] {ECO:0000313|EMBL:EEV00517.1, ECO:0000313|Proteomes:UP000004828}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L1-82 {ECO:0000313|EMBL:EEV00517.1,
RC   ECO:0000313|Proteomes:UP000004828};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Nelson J., Hou S., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Nash W.E., Warren W., Chinwalla A.,
RA   Mardis E.R., Wilson R.K.;
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EEV00517.1}.
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DR   EMBL; ABYJ02000114; EEV00517.1; -; Genomic_DNA.
DR   RefSeq; WP_006857656.1; NZ_GG692726.1.
DR   AlphaFoldDB; C7GCD8; -.
DR   HOGENOM; CLU_563543_0_0_9; -.
DR   Proteomes; UP000004828; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   CDD; cd01949; GGDEF; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR45138:SF9; DIGUANYLATE CYCLASE DGCM-RELATED; 1.
DR   PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF13374; TPR_10; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          121..154
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   DOMAIN          382..518
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
SQ   SEQUENCE   518 AA;  60108 MW;  DFB11F80174E77DE CRC64;
     MGYSLRKCFN ITGKYGIMKQ KVTVFVNGWH MHTESEIEKL AAEYMEEGRT AFFSKELNKA
     ATLTQNAIDI YRMEKNYEQY AFAQNMMGVI YVSLGNESAA MDCYLEVLEC SKRHGITSVL
     ALAYNNIGSR YQELRQHQKA IGYFERSADE LEKVTDTENE NFQIRYLITH MNLMKSYGEL
     DRLDDARKEL LKLEKCSQGI VNEMYRYSYL TLKSRLYWNI GEKEYVYEHL DELIKGGIDD
     SNAADYIEDV SDLCGLLKDM QEFDKWKRVI LAFEQHAKKQ NSIYYEMILN EMWLDYYKEL
     GDNEQYVKLC IHYVDVAQQQ KKADNEERAC AIDLKIELQE KEEQRRHAEV RSNQDALTGL
     GNRYMLEKDA VDVIEHAIKT GEKIAVGVLD IDCFKQHNDT YGHIQGDRCL RHVADVLKNA
     VEKRGKAYRF GGDEFVLLIQ NGEENTITSI AETIKKELQQ LHIEDKDSGR QAAVTISQGY
     ASFLPSRQES RNSLIEHADK ALYEVKENGR DGFRIIVE
//