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Database: UniProt
Entry: C7GLC8_YEAS2
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ID   C7GLC8_YEAS2            Unreviewed;      1063 AA.
AC   C7GLC8;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   11-JUN-2014, entry version 23.
DE   RecName: Full=Transcription elongation factor SPT5;
GN   Name=SPT5; ORFNames=C1Q_00993;
OS   Saccharomyces cerevisiae (strain JAY291) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=574961;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JAY291;
RX   PubMed=19812109; DOI=10.1101/gr.091777.109;
RA   Argueso J.L., Carazzolle M.F., Mieczkowski P.A., Duarte F.M.,
RA   Netto O.V.C., Missawa S.K., Galzerani F., Costa G.G.L., Vidal R.O.,
RA   Noronha M.F., Dominska M., Andrietta M.G.S., Andrietta S.R.,
RA   Cunha A.F., Gomes L.H., Tavares F.C.A., Alcarde A.R., Dietrich F.S.,
RA   McCusker J.H., Petes T.D., Pereira G.A.G.;
RT   "Genome structure of a Saccharomyces cerevisiae strain widely used in
RT   bioethanol production.";
RL   Genome Res. 19:2258-2270(2009).
CC   -!- FUNCTION: The SPT4-SPT5 complex mediates both activation and
CC       inhibition of transcription elongation, and plays a role in pre-
CC       mRNA processing. This complex seems to be important for the
CC       stability of the RNA polymerase II elongation machinery on the
CC       chromatin template but not for the inherent ability of this
CC       machinery to translocate down the gene (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- SIMILARITY: Belongs to the SPT5 family.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data.
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DR   EMBL; ACFL01000033; EEU08445.1; -; Genomic_DNA.
DR   OrthoDB; EOG77WWNF; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR006645; NGN_dom.
DR   InterPro; IPR024945; Spt5_C_dom.
DR   InterPro; IPR022581; Spt5_N.
DR   InterPro; IPR017071; TF_Spt5.
DR   InterPro; IPR005100; TF_Spt5_NGN-domain.
DR   InterPro; IPR008991; Translation_prot_SH3-like.
DR   Pfam; PF03439; Spt5-NGN; 1.
DR   Pfam; PF11942; Spt5_N; 1.
DR   PIRSF; PIRSF036945; Spt5; 1.
DR   SMART; SM01104; CTD; 1.
DR   SMART; SM00739; KOW; 4.
DR   SMART; SM00738; NGN; 1.
DR   SUPFAM; SSF50104; SSF50104; 2.
PE   3: Inferred from homology;
KW   Complete proteome; Nucleus; Transcription.
SQ   SEQUENCE   1063 AA;  115528 MW;  459B8C95674DADDE CRC64;
     MSDNSDTNVS MQDHDQQVAD PVVVPQSTDT KDENTSDKDT VDSGNVTTTE STERAESTSK
     IPPLDGEEKE AKSEPQQPED NAETAATEQV SSSNGPATDG AQATLNTDSS EANEIVKKEE
     GSDERKRPRE EDTKNSDGDT KDEGVNKDDD DDEDDDDDDD DEDDDDEAPT KRRRQERNRF
     LDIEAEVSDD EDEDEDEEDS ELVREGFITH GDDEDDEASA PGARRDDRLH RQLDQDLNKT
     SEEDAQRLAK ELRERYGRSS SKQYRAAAQD GYVPQRFLLP SVDTATIWGV RCRPGKEKEL
     IRKLLKKKFN LDRAMGKKKL KILSIFQRDN YTGRIYIEAP KQSVIEKFCN GVPDIYISQK
     LLIPVQELPL LLKPNKSDDV ALEEGSYVRI KRGIYKGDLA MVDQISENNL EVMLKIVPRL
     DYGKFDEIDP TTQQRKSRRP TFAHRAPPQL FNPTMALRLD QANLYKRDDR HFTYKNEDYI
     DGYLYKSFRI QHVETKNIQP TVEELARFGS KEGAVDLTSV SQSIKKAQAA KVTFQPGDRI
     EVLNGEQRGS KGIVTRTTKD IATIKLNGFT TPLEFPISTL RKIFEPGDHV TVINGEHQGD
     AGLVLMVEQG QVTFMSTQTS REVTITANNL SKSIDTTATS SEYALHDIVE LSAKNVACII
     QAGHDIFKVI DETGKVSTIT KGSILSKINT ARARVSSVDA NGNEIKIGDT IVEKVGSRRE
     GQVLYIQTQQ IFVVSKKIVE NAGVFVVNPS NVEAVASKDN MLSNKMDLSK MNPEIISKMG
     PPSSKTFQQP IQSRGGREVA LGKTVRIRSA GYKGQLGIVK DVNGDKATVE LHSKNKHITI
     DKHKLTYYNR EGGEGITYDE LVNRRGRVPQ ARMGPSYVSA PRNMATGGIA AGAAATSSGL
     SGGMTPGWSS FDGGKTPAVN AHGGSGGGGV SSWGGASTWG GQGNGGASAW GGAGGGASAW
     GGQGTGATST WGGASAWGNK SSWGGASTWA SGGESNGAMS TWGGTGDRSA YGGASTWGGN
     NNNKSTRDGG ASAWGNQDDG NRSAWNNQGN KSNYGGNSTW GGH
//
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