ID SEC11_YEAS2 Reviewed; 167 AA.
AC C7GLT4;
DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT 13-OCT-2009, sequence version 1.
DT 01-MAY-2013, entry version 23.
DE RecName: Full=Signal peptidase complex catalytic subunit SEC11;
DE EC=3.4.21.89;
DE AltName: Full=Secretory protein 11;
DE AltName: Full=Signal peptidase I;
GN Name=SEC11; ORFNames=C1Q_01195;
OS Saccharomyces cerevisiae (strain JAY291) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=574961;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JAY291;
RX PubMed=19812109; DOI=10.1101/gr.091777.109;
RA Argueso J.L., Carazzolle M.F., Mieczkowski P.A., Duarte F.M.,
RA Netto O.V.C., Missawa S.K., Galzerani F., Costa G.G.L., Vidal R.O.,
RA Noronha M.F., Dominska M., Andrietta M.G.S., Andrietta S.R.,
RA Cunha A.F., Gomes L.H., Tavares F.C.A., Alcarde A.R., Dietrich F.S.,
RA McCusker J.H., Petes T.D., Pereira G.A.G.;
RT "Genome structure of a Saccharomyces cerevisiae strain widely used in
RT bioethanol production.";
RL Genome Res. 19:2258-2270(2009).
CC -!- FUNCTION: Catalytic component of the signal peptidase complex
CC (SPC), which catalyzes the cleavage of N-terminal signal sequences
CC of proteins targeted to the endoplasmic reticulum. Signal peptide
CC cleavage occurs during the translocation (cotranslationally or
CC post-translationally) through the translocon pore into the
CC endoplasmic reticulum (By similarity).
CC -!- CATALYTIC ACTIVITY: Cleavage of hydrophobic, N-terminal signal or
CC leader sequences from secreted and periplasmic proteins.
CC -!- SUBUNIT: Component of the signal peptidase complex (SPC), which
CC consists of SPC1, SPC2, SPC3 and SEC11 (By similarity). SPC
CC associates with the translocon complex (By similarity).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC type II membrane protein (By similarity).
CC -!- SIMILARITY: Belongs to the peptidase S26B family.
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DR EMBL; ACFL01000039; EEU08253.1; -; Genomic_DNA.
DR ProteinModelPortal; C7GLT4; -.
DR SMR; C7GLT4; 38-88.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005787; C:signal peptidase complex; IEA:InterPro.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR InterPro; IPR019756; Pept_S26A_signal_pept_1_Ser-AS.
DR InterPro; IPR019759; Peptidase_S24_S26.
DR InterPro; IPR015927; Peptidase_S24_S26A/B/C.
DR InterPro; IPR001733; Peptidase_S26B.
DR InterPro; IPR027245; Sec11.
DR PANTHER; PTHR10806; PTHR10806; 1.
DR PANTHER; PTHR10806:SF2; PTHR10806:SF2; 1.
DR Pfam; PF00717; Peptidase_S24; 1.
DR PRINTS; PR00728; SIGNALPTASE.
DR SUPFAM; SSF51306; Pept_S24_S26_C; 1.
DR TIGRFAMs; TIGR02228; sigpep_I_arch; 1.
DR PROSITE; PS00501; SPASE_I_1; 1.
DR PROSITE; PS00761; SPASE_I_3; 1.
PE 3: Inferred from homology;
KW Complete proteome; Endoplasmic reticulum; Glycoprotein; Hydrolase;
KW Membrane; Protease; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1 167 Signal peptidase complex catalytic
FT subunit SEC11.
FT /FTId=PRO_0000412356.
FT TOPO_DOM 1 9 Cytoplasmic (Potential).
FT TRANSMEM 10 30 Helical; Signal-anchor for type II
FT membrane protein; (Potential).
FT TOPO_DOM 31 167 Lumenal (Potential).
FT ACT_SITE 44 44 By similarity.
FT CARBOHYD 121 121 N-linked (GlcNAc...) (Potential).
SQ SEQUENCE 167 AA; 18762 MW; FC877232D6888DF3 CRC64;
MNLRFELQKL LNVCFLFASA YMFWQGLAIA TNSASPIVVV LSGSMEPAFQ RGDILFLWNR
NTFNQVGDVV VYEVEGKQIP IVHRVLRQHN NHADKQFLLT KGDNNAGNDI SLYANKKIYL
NKSKEIVGTV KGYFPQLGYI TIWISENKYA KFALLGMLGL SALLGGE
//
