ID C7HSP5_9FIRM Unreviewed; 1139 AA.
AC C7HSP5;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=HMPREF0078_0296 {ECO:0000313|EMBL:EEU13161.1};
OS Anaerococcus vaginalis ATCC 51170.
OC Bacteria; Bacillota; Tissierellia; Tissierellales; Peptoniphilaceae;
OC Anaerococcus.
OX NCBI_TaxID=655811 {ECO:0000313|EMBL:EEU13161.1, ECO:0000313|Proteomes:UP000003821};
RN [1] {ECO:0000313|EMBL:EEU13161.1, ECO:0000313|Proteomes:UP000003821}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51170 {ECO:0000313|EMBL:EEU13161.1,
RC ECO:0000313|Proteomes:UP000003821};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R., Gibbs R.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEU13161.1}.
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DR EMBL; ACXU01000005; EEU13161.1; -; Genomic_DNA.
DR AlphaFoldDB; C7HSP5; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_001114_3_1_9; -.
DR Proteomes; UP000003821; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014152; AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02785; addA_Gpos; 1.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000003821}.
FT DOMAIN 12..459
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 471..747
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 33..40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1139 AA; 134640 MW; 7773E5E98DF0760F CRC64;
MILKRSNQMS KFKPTDDQKK AIETRGKNII VSAAAGSGKT RVLVDRLVSI MLEEKIPIKN
MIIVTFTNKA SVEMKDRIRQ KLNELMKEGN SDKIFIKNQI KSINDAFIKT LHSFCADMLR
ENFYLSDNLS PSFKIAADSK QALLRKDAID ELFEDEYEKN DSNFINFLHN FASSKDDKDA
KNIILDLYDF SKSQINPHQW LCDNTNNNFD FEKFKFYIKE RIETIILNAR DLEDYIKEKS
MRDKYFIMIE KDLSYLEKIK NSIEEKTWDE VIEIFENGLA NMVTISKKLD DPNENAYVKA
KKNAYKDEFN IVKDFVKNTD SITRGFFNPL EDKILNELKN LVFSFEKIYT NKKREENYLD
FSDMEHEFIK LLDNEKLQSK LKKQFKYIFF DEYQDSNDIQ NYIVEKLKNE NNLFFVGDVK
QSIYGFRNAR PELFLKKLEG YDTDSNCLRI NLSKNFRTDK DLIDFNNYIF DRLMTRKNSD
IAYKDDNHRL NYHFEFDEKY PKVSIKALAK NVSEEAYLTK EINNLINSGL EYKDIAILLR
SSSKAYLFEN ELKRAGIPFS SDISKISFET VEVEFFINIL KYIANPNDDI SLLSVLRSEI
FNFSEDDLAE ISLSSEKSHF YKKFKEYEKE NENNLSQKIS DFNTIFTDFS YILNFSTMYD
FANIIFEKSG FYDFLKARDR GEERVKNIEA FIELMDDYDK NNENSLFGFL AYIDNLKNQK
KDNLKASRNL SDDENLVRIM TIHKSKGLEF KAVILPDFSK RFNTRDNSKD MVLDKDLGIG
INIADWENKI KISSIKRDLI LEKSNLNDKK EEMRVLYVAL TRAERKISII GKKDLNQKGL
EKILNANSVL DLSSYMDWIL KILCDDKIMS DFIDIDYKTD AFNKGFLEIK YIEDFIEDYK
KDYTDVEKLI GADEYNQKIY KDIEEVFNFS YKNKENINKS LKKSVTEIAK NYDLSKDGYE
KSPFEENEAF YEFRKPNFEE IKLSATDKGT LIHKIFQELE VKSYDLNSLE KEINKLVDLG
KIKKEYLPYI NFENILGFFN SKIIQDLMKK SPKIRKEESF LRKIDDFYVN GQIDIMFESQ
NEVVLMDFKT DSIKREGFYD KQLEIYKDSI EEALGKKVIS SYIYWYNFKE FEQVNKNHH
//
