ID C7HV16_9FIRM Unreviewed; 343 AA.
AC C7HV16;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=3-dehydroquinate synthase {ECO:0000313|EMBL:EEU12465.1};
DE EC=4.2.3.4 {ECO:0000313|EMBL:EEU12465.1};
GN Name=aroB {ECO:0000313|EMBL:EEU12465.1};
GN ORFNames=HMPREF0078_1073 {ECO:0000313|EMBL:EEU12465.1};
OS Anaerococcus vaginalis ATCC 51170.
OC Bacteria; Bacillota; Tissierellia; Tissierellales; Peptoniphilaceae;
OC Anaerococcus.
OX NCBI_TaxID=655811 {ECO:0000313|EMBL:EEU12465.1, ECO:0000313|Proteomes:UP000003821};
RN [1] {ECO:0000313|EMBL:EEU12465.1, ECO:0000313|Proteomes:UP000003821}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51170 {ECO:0000313|EMBL:EEU12465.1,
RC ECO:0000313|Proteomes:UP000003821};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R., Gibbs R.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC Evidence={ECO:0000256|ARBA:ARBA00001941};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEU12465.1}.
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DR EMBL; ACXU01000015; EEU12465.1; -; Genomic_DNA.
DR RefSeq; WP_004839116.1; NZ_GG700527.1.
DR AlphaFoldDB; C7HV16; -.
DR GeneID; 79022349; -.
DR eggNOG; COG0337; Bacteria.
DR HOGENOM; CLU_001201_0_1_9; -.
DR Proteomes; UP000003821; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0003856; F:3-dehydroquinate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:InterPro.
DR CDD; cd08195; DHQS; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR016037; DHQ_synth_AroB.
DR InterPro; IPR030963; DHQ_synth_fam.
DR InterPro; IPR030960; DHQS/DOIS.
DR NCBIfam; TIGR01357; aroB; 1.
DR PANTHER; PTHR43622; 3-DEHYDROQUINATE SYNTHASE; 1.
DR PANTHER; PTHR43622:SF1; 3-DEHYDROQUINATE SYNTHASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01761; DHQ_synthase; 1.
DR PIRSF; PIRSF001455; DHQ_synth; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
PE 4: Predicted;
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:EEU12465.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000003821};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 64..310
FT /note="3-dehydroquinate synthase"
FT /evidence="ECO:0000259|Pfam:PF01761"
SQ SEQUENCE 343 AA; 39316 MW; 6910F6818805B161 CRC64;
MKLSVDLINP YEIEIGSNII KKLNTYLKEN YKNSKILIIS DDLVYKIHKE KLIKELDGFF
YKEFIIKNGE NSKSTENLIK ILEFAAENQY KRNDLIIAFG GGVVGDISGL VASLYLRGVD
YISIPTTFLS AIDSSVGGKT AVNLKAGKNL CGTFYQPKKV FIDTDFLKTL SDYYFNDGLA
EAIKYGMIKD KSIFDEISKE NVSKTYENLP SIIKKCLDIK KDVVKDDEKD FGIRQILNYG
HTFAHAIEKN SNFEISHGHA VALGMKIMVK NFYESFYDDF IKVLKKYNLD KEIDFDTEKI
LKVCMVDKKS RNDRINIIVV RNLGTCEILN IDLKDLRKIY ENR
//
