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Database: UniProt
Entry: C7JHC5_ACEP3
LinkDB: C7JHC5_ACEP3
Original site: C7JHC5_ACEP3 
ID   C7JHC5_ACEP3            Unreviewed;       477 AA.
AC   C7JHC5;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   25-OCT-2017, entry version 66.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:BAH99379.1};
GN   OrderedLocusNames=APA01_12320 {ECO:0000313|EMBL:BAH99379.1};
OS   Acetobacter pasteurianus (strain NBRC 3283 / LMG 1513 / CCTM 1153).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Acetobacter.
OX   NCBI_TaxID=634452 {ECO:0000313|EMBL:BAH99379.1, ECO:0000313|Proteomes:UP000000948};
RN   [1] {ECO:0000313|EMBL:BAH99379.1, ECO:0000313|Proteomes:UP000000948}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 3283 / LMG 1513 / CCTM 1153
RC   {ECO:0000313|Proteomes:UP000000948};
RX   PubMed=19638423; DOI=10.1093/nar/gkp612;
RA   Azuma Y., Hosoyama A., Matsutani M., Furuya N., Horikawa H.,
RA   Harada T., Hirakawa H., Kuhara S., Matsushita K., Fujita N.,
RA   Shirai M.;
RT   "Whole-genome analyses reveal genetic instability of Acetobacter
RT   pasteurianus.";
RL   Nucleic Acids Res. 37:5768-5783(2009).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; AP011121; BAH99379.1; -; Genomic_DNA.
DR   RefSeq; WP_012812906.1; NC_013209.1.
DR   ProteinModelPortal; C7JHC5; -.
DR   STRING; 634452.APA01_12320; -.
DR   EnsemblBacteria; BAH99379; BAH99379; APA01_12320.
DR   GeneID; 8435321; -.
DR   KEGG; apt:APA01_12320; -.
DR   PATRIC; fig|634452.3.peg.1299; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235660; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000000948; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000948};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000948}.
FT   DOMAIN      175    378       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      385    454       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     183    190       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   477 AA;  53138 MW;  A5173506AB5AFB33 CRC64;
     MTIGVDDDES AFSRLEDGKG LEESWLRICA RLKGEVGEVE YRTWLTKIAL GPIDGDEITL
     LLPTRFLRDW VRSQYGDRLS ELWNQEIPSI RRVELQVARA GDPAPIPLEN VPSTAAATPA
     QEEATPAART APEVRSDLVT ALDSRFTFDT FVVGKPNEFA YACARRVAEK PSSVGFNPLF
     LYGGVGLGKT HLMHAIGAEL IQSGNVSVAY MSAEKFMYRF IAAIRSQSTI EFKEQLRSVD
     VLMIDDLQFL IGKDNTQEEF FHTFNALVDA GRQIVVSADK SPSDLSGLED RLRTRLGCGM
     VADIHATTFE LRISILESKA AASGVVVPGK VLEFLAHKIT SNVRELEGAL NRLIAHANLF
     GRPVTLEATQ EVLHDILKAH DRRVTIEEIQ KKVAEHWNIR LTDMSSARRA RNVARPRQVA
     MYLAKQLTSR SLPEIGRKFG NRDHTTVMHA VNRVTELMGL DAAFAEDVEL LRRMLES
//
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