ID C7LFK3_BRUMC Unreviewed; 910 AA.
AC C7LFK3;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:ACU47168.1};
GN OrderedLocusNames=BMI_I150 {ECO:0000313|EMBL:ACU47168.1};
OS Brucella microti (strain CCM 4915).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=568815 {ECO:0000313|EMBL:ACU47168.1, ECO:0000313|Proteomes:UP000002188};
RN [1] {ECO:0000313|EMBL:ACU47168.1, ECO:0000313|Proteomes:UP000002188}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCM 4915 {ECO:0000313|EMBL:ACU47168.1,
RC ECO:0000313|Proteomes:UP000002188};
RX PubMed=19653890; DOI=10.1186/1471-2164-10-352;
RA Audic S., Lescot M., Claverie J.-M., Scholz H.C.;
RT "Brucella microti: the genome sequence of an emerging pathogen.";
RL BMC Genomics 10:352-352(2009).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP001578; ACU47168.1; -; Genomic_DNA.
DR RefSeq; WP_012783836.1; NC_013119.1.
DR AlphaFoldDB; C7LFK3; -.
DR KEGG; bmr:BMI_I150; -.
DR HOGENOM; CLU_002472_4_0_5; -.
DR PhylomeDB; C7LFK3; -.
DR Proteomes; UP000002188; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 732..748
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 534..561
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 658..665
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 910 AA; 98724 MW; C6A535706F38729D CRC64;
MEAKVEEKEP EPVENAGPDA PVRLTPMMEQ YIEIKAANVD SLLFYRMGDF YELFFDDAVA
ASAALGITLT KRGKHLGEDI PMCGVPVHAA DDYLQKLIAK GYRVAVCEQV EDPAEAKKRG
SKSVVKRDVI RLVTPGTLTE EKLLDPAQAN FLMAMGRTRG DGALALAWID ISTGTFRVAE
TTPDRLFADI MRVDPRELVV ADSAFHDEEL RPVFDLIGKA VAPQPATLFD SAAAQTRIQH
YFNVATLDGF GQFSRPELSA ISGAIAYIEK TQISERPPLM RPEREHEGGT LFIDPATRAS
LELARTMSGN RDGSLLKAID RTVTGGGARL LAERLTAPLT SPKEIALRLD SVSWCLSEQT
LCEALRLELK GVPDMPRALS RLAVGRGGPR DLGALACGFE AAGGIASLLD GALLPDELAA
AREAIEKMPA GFAAHLDRAL ADELPLLKRD GGFVREGYNS ELDEMRALRD QSRRVIAGLQ
ADYIEETGIK SLKIKHNNVL GYFIEVTANN SGAMTDTDEA KSRFIHRQTM ANAMRFTTTE
LAELESKIAN AADRALSIEL AIFEELTAEA VAHADSIRAA ASALSVFDVS TALAVLAEEQ
GYCRPHVDDS LSFNIVAGRH PVVEQALRCQ AANPFVANDC DLSPQRDGGD GAIWLLTGPN
MGGKSTFLRQ NALIAILAQM GSFVPAGSAH IGVVDRLFSR VGASDDLARG RSTFMVEMVE
TAAILNQAGE HSLVILDEIG RGTATFDGLS IAWAAVEYLH EKNRCRALFA THFHEMTALS
EKLERLSNVT MRVKEWDNDV IFLHEVAKGA ADRSYGVQVA RLAGLPEAVV NRARDVLHQL
EAGETSGKAD RLIDDLPLFS VMLQQEKPKP QIQAKDSELA NAVAAISPDE LTPREALDLI
YKLKELAGKA
//
