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Database: UniProt
Entry: C7LWW2_DESBD
LinkDB: C7LWW2_DESBD
Original site: C7LWW2_DESBD 
ID   C7LWW2_DESBD            Unreviewed;       426 AA.
AC   C7LWW2;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   05-JUL-2017, entry version 69.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   OrderedLocusNames=Dbac_3097 {ECO:0000313|EMBL:ACU91172.1};
OS   Desulfomicrobium baculatum (strain DSM 4028 / VKM B-1378)
OS   (Desulfovibrio baculatus).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfomicrobiaceae; Desulfomicrobium.
OX   NCBI_TaxID=525897 {ECO:0000313|EMBL:ACU91172.1, ECO:0000313|Proteomes:UP000002216};
RN   [1] {ECO:0000313|EMBL:ACU91172.1, ECO:0000313|Proteomes:UP000002216}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 4028 / VKM B-1378 {ECO:0000313|Proteomes:UP000002216};
RX   PubMed=21304634; DOI=10.4056/sigs.13134;
RA   Copeland A., Spring S., Goker M., Schneider S., Lapidus A.,
RA   Del Rio T.G., Tice H., Cheng J.F., Chen F., Nolan M., Bruce D.,
RA   Goodwin L., Pitluck S., Ivanova N., Mavrommatis K., Ovchinnikova G.,
RA   Pati A., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA   Jeffries C.C., Meincke L., Sims D., Brettin T., Detter J.C., Han C.,
RA   Chain P., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Lucas S.;
RT   "Complete genome sequence of Desulfomicrobium baculatum type strain
RT   (X).";
RL   Stand. Genomic Sci. 1:29-37(2009).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001629; ACU91172.1; -; Genomic_DNA.
DR   RefSeq; WP_015775261.1; NC_013173.1.
DR   STRING; 525897.Dbac_3097; -.
DR   EnsemblBacteria; ACU91172; ACU91172; Dbac_3097.
DR   KEGG; dba:Dbac_3097; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000227577; -.
DR   KO; K02313; -.
DR   OMA; DFRYLQG; -.
DR   OrthoDB; POG091H02FF; -.
DR   BioCyc; DBAC525897:GI50-3107-MONOMER; -.
DR   Proteomes; UP000002216; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS01008; DNAA; 1.
DR   PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002216};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002216}.
FT   DOMAIN      124    245       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      327    396       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   426 AA;  48484 MW;  D55A4B1D55F29FC1 CRC64;
     MNGAQVEVAL TQAFSAEELD KWRASLGLSV EGSVLTVRFP HRYFSDWFET HARVRFEQAL
     AGSGLSIAYE CRDRSRSRIV RESRPAGQAL PFGSEFIFDN FLVNNKNYFP LASAQEVAQS
     REAPYNPFVL CGESGSGKSF LLRAIANARS EHGADGSYVG GIEDLHELYS SRSDARKFLT
     SMQLLAVDDL QEIARYRYLQ GELLALFDHF HLQRKQMVFA CTGKVGGYTF LAPKLKSRLE
     WGLSVMLKAP DLDIRTQYAQ SRCRERRLDL SKDRILLLAQ RFADLRNLEG CLLKLWAYRE
     LVHDHISDEE FDNILNYLDD RAVTSLSVEQ ILDAVCSKFN LKPEDILSSG RRHDLVFARQ
     VAMYLCRKHL GLSFPELGRA FGGRDHSTVL YSCRKVEQLQ RDDKSIKNML HELSDKCLAM
     NETTLA
//
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