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Database: UniProt
Entry: C7MID5_MYCML
LinkDB: C7MID5_MYCML
Original site: C7MID5_MYCML 
ID   C7MID5_MYCML            Unreviewed;       450 AA.
AC   C7MID5;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   25-OCT-2017, entry version 54.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:ACU78234.1};
GN   ORFNames=MMCAP2_0001 {ECO:0000313|EMBL:ACU78234.1};
OS   Mycoplasma mycoides subsp. capri str. GM12.
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=436113 {ECO:0000313|EMBL:ACU78234.1, ECO:0000313|Proteomes:UP000011126};
RN   [1] {ECO:0000313|EMBL:ACU78234.1, ECO:0000313|Proteomes:UP000011126}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GM12 {ECO:0000313|EMBL:ACU78234.1};
RX   PubMed=19696314; DOI=10.1126/science.1173759;
RA   Lartigue C., Vashee S., Algire M.A., Chuang R.Y., Benders G.A., Ma L.,
RA   Noskov V.N., Denisova E.A., Gibson D.G., Assad-Garcia N.,
RA   Alperovich N., Thomas D.W., Merryman C., Hutchison C.A.III.,
RA   Smith H.O., Venter J.C., Glass J.I.;
RT   "Creating bacterial strains from genomes that have been cloned and
RT   engineered in yeast.";
RL   Science 325:1693-1696(2009).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001668; ACU78234.1; -; Genomic_DNA.
DR   EnsemblBacteria; ACU78234; ACU78234; MMCAP2_0001.
DR   PATRIC; fig|436113.7.peg.1; -.
DR   Proteomes; UP000011126; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011126};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011126}.
FT   DOMAIN      140    265       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      357    426       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     148    155       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   450 AA;  51703 MW;  0385625E99EC48C7 CRC64;
     MNVNDILKEL KLSLMANKNI DESVYNDYIK TINIHKKGFS DYIVVVKSQF GLLAIKQFRQ
     TIENEIKNIL KEPVNISFTY EQEYKKQLEK DELINKDHSD IITKKVKKTN ENTFENFVIG
     ASNEQAFIAV QTVSKNPGIS YNPLFIYGES GMGKTHLLKA AKNYIESNFS DLKVSYMSGD
     EFARKAVDIL QKTHKEIEQF KNEVCQNDVL IIDDVQFLSY KEKTNEIFFT IFNNFIENDK
     QLFFSSDKSP ELLNGFDNRL ITRFNMGLSI AIQKLDNKTA TAIIKKEIKN QNIKSEVTSE
     AINFISNYYS DDVRKIKGSV SRLNFWSQQN PEEKIITIEI ISDLFRDIPT SKLGILNVKK
     IKEVVSEKYG ISVNAIDGKA RSKSIVTARH IAMFLTKEIL NHTLAQIGEE FGGRDHTTVI
     NAERKIETML KKDKQLKKTV DILKNKILTK
//
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