ID C7N255_SLAHD Unreviewed; 1131 AA.
AC C7N255;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Shel_02930 {ECO:0000313|EMBL:ACV21361.1};
OS Slackia heliotrinireducens (strain ATCC 29202 / DSM 20476 / NCTC 11029 /
OS RHS 1) (Peptococcus heliotrinreducens).
OC Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC Slackia.
OX NCBI_TaxID=471855 {ECO:0000313|EMBL:ACV21361.1, ECO:0000313|Proteomes:UP000002026};
RN [1] {ECO:0000313|EMBL:ACV21361.1, ECO:0000313|Proteomes:UP000002026}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29202 / DSM 20476 / NCTC 11029 / RHS 1
RC {ECO:0000313|Proteomes:UP000002026};
RX PubMed=21304663; DOI=10.4056/sigs.37633;
RA Pukall R., Lapidus A., Nolan M., Copeland A., Glavina Del Rio T., Lucas S.,
RA Chen F., Tice H., Cheng J.F., Chertkov O., Bruce D., Goodwin L., Kuske C.,
RA Brettin T., Detter J.C., Han C., Pitluck S., Pati A., Mavrommatis K.,
RA Ivanova N., Ovchinnikova G., Chen A., Palaniappan K., Schneider S.,
RA Rohde M., Chain P., D'haeseleer P., Goker M., Bristow J., Eisen J.A.,
RA Markowitz V., Kyrpides N.C., Klenk H.P., Hugenholtz P.;
RT "Complete genome sequence of Slackia heliotrinireducens type strain (RHS
RT 1).";
RL Stand. Genomic Sci. 1:234-241(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP001684; ACV21361.1; -; Genomic_DNA.
DR RefSeq; WP_012797470.1; NC_013165.1.
DR AlphaFoldDB; C7N255; -.
DR STRING; 471855.Shel_02930; -.
DR REBASE; 21789; SheORF2930P.
DR KEGG; shi:Shel_02930; -.
DR eggNOG; COG0286; Bacteria.
DR eggNOG; COG1002; Bacteria.
DR HOGENOM; CLU_007510_1_0_11; -.
DR Proteomes; UP000002026; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR047939; BREX_1_PglX.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF033452; BREX_1_MTaseX; 1.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002026};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 284..355
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 451..534
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 1131 AA; 126791 MW; 906332B30738504A CRC64;
MDSSRIKRLA TGVRDELRRE VEGRLEAVLA ADSPERLSDG TGVVRLEARI EAEGRDAVVE
AGAYTWFNRL CALRFMDARG YTPTPAVTPR AGSTMPAVLA DAAQGSFDPE YGLAPAVRER
VVSLLSGSTQ RANATEAAYA ELLRAVCAHY AKPMPYLFSE DAASSLLMPR GLLSEGSILG
RIVAEMDAGA CSSVEVLGWL YQFYIAELHD QVYSGFKRSV KAGPAEIGPA TQLFTPEWIV
RYLCENSLGR LWMLNHPGSP LAERMDYYIA PEGDEPHIEV SSAEEVRVLD PACGSGHILV
YAFDLLYSMY EEEGWLPEEI PAMILQNNLK GLEIDARAAE IAKFALEMKA LERDPRFLER
DVDADVTVLR PVALDEADMP YLSQSFKERV GLIEAMAHMG EVGSLYVPEA GDARAVAAEI
ERLAPKAQSD MFARDLAGRL GAMLENVEAL SGSYHCVVAN PPYLGSGNMS TYLSRWCKGN
YPDAKADLCT CFIERCLHFT KQYGVESIIT SDTCMYISSF EKLRRKILEQ TTLYSFLDTR
GTNAHPDVFD ANAGWILGKG HLSGVKGSFF KLSHRTSEKD TALLNAIHNP KCGWLYKADT
DLFKTIPGCP IAYLVSETMM GAFRNLGNVA SLGRASVGIK TGNNGAFLRF WWEVARGKIL
FNGVSSDATF IEGYRWYPCN KGGAFRKWYG NAEYVVDWRE NGKYAFESAE KNGNHAQDYS
DDLKFRPYIT WSDVTSGEQS FRLKTNDLSE MTGMGIYPDD DSRNALLGLL NSSVAKRYLE
LLAPTMHLKI RELGSIPWND DSRCDEVRRT VDTNVAVARK DWDSFETSWD FERHPLARTS
RVEDAFALWQ SECRSRFDQL KANEEKLNRV FARIYGMEGE VPIEVSDDKV SVRLADLQRD
VKSLISYGVG CIFGRYSLDA PGFVLANQGD TARDFLAKVP DPSFVPDEDN ILPVLDAEWF
DDDVVTQFYR FLAAAYGEST LDENVAFIEG ALGCDLRTYF VRDFYSDHVK TYQKRPIYWL
FQSPQKGFSC LVYMHRYSEG TVGEILTKYL RAYEDKLRLR VQVLGRSERA ADLKAADRMR
AQISELEAWE KEVVYPLAHE RVAIDLDDGV KINYNKFPHA LAKVQGLSDW R
//
