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Database: UniProt
Entry: C7NID0_KYTSD
LinkDB: C7NID0_KYTSD
Original site: C7NID0_KYTSD 
ID   C7NID0_KYTSD            Unreviewed;       506 AA.
AC   C7NID0;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   05-JUL-2017, entry version 62.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Ksed_00010 {ECO:0000313|EMBL:ACV05101.1};
OS   Kytococcus sedentarius (strain ATCC 14392 / DSM 20547 / CCM 314 / 541)
OS   (Micrococcus sedentarius).
OC   Bacteria; Actinobacteria; Micrococcales; Dermacoccaceae; Kytococcus.
OX   NCBI_TaxID=478801 {ECO:0000313|EMBL:ACV05101.1, ECO:0000313|Proteomes:UP000006666};
RN   [1] {ECO:0000313|EMBL:ACV05101.1, ECO:0000313|Proteomes:UP000006666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14392 / DSM 20547 / CCM 314 / 541
RC   {ECO:0000313|Proteomes:UP000006666};
RX   PubMed=21304632; DOI=10.4056/sigs.761;
RA   Sims D., Brettin T., Detter J.C., Han C., Lapidus A., Copeland A.,
RA   Glavina Del Rio T., Nolan M., Chen F., Lucas S., Tice H., Cheng J.F.,
RA   Bruce D., Goodwin L., Pitluck S., Ovchinnikova G., Pati A.,
RA   Ivanova N., Mavrommatis K., Chen A., Palaniappan K., D'haeseleer P.,
RA   Chain P., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Schneider S., Goker M., Pukall R., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Kytococcus sedentarius type strain
RT   (541).";
RL   Stand. Genomic Sci. 1:12-20(2009).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001686; ACV05101.1; -; Genomic_DNA.
DR   STRING; 478801.Ksed_00010; -.
DR   EnsemblBacteria; ACV05101; ACV05101; Ksed_00010.
DR   KEGG; kse:Ksed_00010; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000006666; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006666};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006666}.
FT   DOMAIN      196    326       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      408    477       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     204    211       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   506 AA;  55052 MW;  C4956670BC1DD0F1 CRC64;
     MSQTPDDHAT AIWQEAMVHL QGAGLAPRDI GVLRLATLVG LLEGTALLAV KYDHVKDAVE
     GHLREDVSTA LAEVLDRDIR LAVSVDPDAV SAAQEEAAPP APSPADEDDP ATGEGPLSTA
     VDGAVEKHEG SSPARAGESV APATTASLTA TNSSPGVERD YSALNHKYTF DTFVLGSSNR
     FAHAAATAVA EAPARAYNPL FIYGGSGLGK THLLHAIGHY ARTLDSSVRV KYVNSEEFTN
     QFINAVSAGQ ANAFQRQYRD VDVLLIDDIQ FLQGKEQTME EFFHTFNTLH NSEKQIVITS
     DQPPKKLSGF AERMRSRFEW GLLTDVQPPD LETRIAILRR KAAADKLDIP DDVLHLIASK
     ISSNIRELEG ALTRVTAFAS LSGSPLDEYL ARTVLKDVMP GGDSGQITPT MILEETAGYF
     VISVEEIQGA SRSRNLTRAR QIAMYLCREL TDLSLPKIGK EFGGRDHTTV MHAERKIKQL
     LGEDRRVYDE VSELTSIIRK KAARGR
//
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