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Database: UniProt
Entry: C7P1P5_HALMD
LinkDB: C7P1P5_HALMD
Original site: C7P1P5_HALMD 
ID   C7P1P5_HALMD            Unreviewed;       327 AA.
AC   C7P1P5;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   28-MAR-2018, entry version 60.
DE   RecName: Full=Transcription initiation factor IIB {ECO:0000256|HAMAP-Rule:MF_00383};
DE            Short=TFIIB {ECO:0000256|HAMAP-Rule:MF_00383};
GN   Name=tfb {ECO:0000256|HAMAP-Rule:MF_00383};
GN   OrderedLocusNames=Hmuk_3030 {ECO:0000313|EMBL:ACV49135.1};
OS   Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 /
OS   NCIMB 13541) (Haloarcula mukohataei).
OC   Archaea; Euryarchaeota; Halobacteria; Halobacteriales; Haloarculaceae;
OC   Halomicrobium.
OX   NCBI_TaxID=485914 {ECO:0000313|EMBL:ACV49135.1, ECO:0000313|Proteomes:UP000001746};
RN   [1] {ECO:0000313|EMBL:ACV49135.1, ECO:0000313|Proteomes:UP000001746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541
RC   {ECO:0000313|Proteomes:UP000001746};
RX   PubMed=21304667; DOI=10.4056/sigs.42644;
RA   Tindall B.J., Schneider S., Lapidus A., Copeland A.,
RA   Glavina Del Rio T., Nolan M., Lucas S., Chen F., Tice H., Cheng J.F.,
RA   Saunders E., Bruce D., Goodwin L., Pitluck S., Mikhailova N., Pati A.,
RA   Ivanova N., Mavrommatis K., Chen A., Palaniappan K., Chain P.,
RA   Land M., Hauser L., Chang Y.J., Jeffries C.D., Brettin T., Han C.,
RA   Rohde M., Goker M., Bristow J., Eisen J.A., Markowitz V.,
RA   Hugenholtz P., Klenk H.P., Kyrpides N.C., Detter J.C.;
RT   "Complete genome sequence of Halomicrobium mukohataei type strain
RT   (arg-2).";
RL   Stand. Genomic Sci. 1:270-277(2009).
CC   -!- FUNCTION: Stabilizes TBP binding to an archaeal box-A promoter.
CC       Also responsible for recruiting RNA polymerase II to the pre-
CC       initiation complex (DNA-TBP-TFIIB). {ECO:0000256|HAMAP-
CC       Rule:MF_00383}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00383};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-
CC       Rule:MF_00383};
CC   -!- SIMILARITY: Belongs to the TFIIB family. {ECO:0000256|HAMAP-
CC       Rule:MF_00383}.
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DR   EMBL; CP001688; ACV49135.1; -; Genomic_DNA.
DR   RefSeq; WP_015763977.1; NC_013202.1.
DR   STRING; 485914.Hmuk_3030; -.
DR   EnsemblBacteria; ACV49135; ACV49135; Hmuk_3030.
DR   GeneID; 8412583; -.
DR   KEGG; hmu:Hmuk_3030; -.
DR   eggNOG; arCOG01981; Archaea.
DR   eggNOG; COG1405; LUCA.
DR   HOGENOM; HOG000108633; -.
DR   KO; K03124; -.
DR   OMA; NEIARTY; -.
DR   OrthoDB; POG093Z07LX; -.
DR   Proteomes; UP000001746; Chromosome.
DR   GO; GO:0003700; F:DNA binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0070897; P:DNA-templated transcriptional preinitiation complex assembly; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 1.
DR   HAMAP; MF_00383; TF2B_arch; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023484; TFIIB_arc.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618; PTHR11618; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 2.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; SSF47954; 2.
DR   PROSITE; PS00782; TFIIB; 1.
DR   PROSITE; PS51134; ZF_TFIIB; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001746};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00383, ECO:0000256|PROSITE-
KW   ProRule:PRU00469};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001746};
KW   Repeat {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00383};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00383, ECO:0000256|PROSITE-
KW   ProRule:PRU00469};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00469}.
FT   DOMAIN       28     58       TFIIB-type. {ECO:0000259|PROSITE:
FT                                PS51134}.
FT   REPEAT      144    227       1. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   REPEAT      238    319       2. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   ZN_FING      28     58       TFIIB-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00469}.
FT   METAL        32     32       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        35     35       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        50     50       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
FT   METAL        53     53       Zinc. {ECO:0000256|HAMAP-Rule:MF_00383}.
SQ   SEQUENCE   327 AA;  36324 MW;  CE4B54009DDBB31C CRC64;
     MSDSNTRTRA RTRTTTDEEQ TEEESETTST ACPECSGTLV VDDEHGETVC EDCGLVVETD
     EIDRGPEWRA FDSSEKDEKS RVGAPTTNMM HDKGLSTNID WRDKDAYGNS LSGKQRQKMQ
     RLRKWNERFR TRDSKERNLK QALGEIDRMA SAVGLPENVR ETASVIYRRA LDENLLPGRS
     IEGVSTASVY AAARQAGVPR SLDEIDEVSR VEKSEIARTY RYVVRELGLE VAPADPESYV
     PRFASSLELS DEAEHRARQL LQNAKEQGVH SGKSPVGLAA AAVYAAALLT NEKTTQAAVS
     EVADISEVTI RNRYHELLEA EQGLPMA
//
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