ID C7SW01_9SECO Unreviewed; 1095 AA.
AC C7SW01;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=RNA2 polyprotein {ECO:0000256|ARBA:ARBA00022361};
DE AltName: Full=Genome polyprotein M {ECO:0000256|ARBA:ARBA00032125};
DE AltName: Full=M RNA polyprotein {ECO:0000256|ARBA:ARBA00033402};
DE AltName: Full=Middle component RNA polyprotein {ECO:0000256|ARBA:ARBA00030233};
DE AltName: Full=P2 {ECO:0000256|ARBA:ARBA00031918};
OS Turnip ringspot virus.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Secoviridae; Comovirinae; Comovirus.
OX NCBI_TaxID=392504 {ECO:0000313|EMBL:ACV41392.1, ECO:0000313|Proteomes:UP000202412};
RN [1] {ECO:0000313|EMBL:ACV41392.1, ECO:0000313|Proteomes:UP000202412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Toledo {ECO:0000313|EMBL:ACV41392.1};
RX PubMed=19838619; DOI=10.1007/s00705-009-0523-5;
RA Khandekar S., He J., Leisner S.;
RT "Complete nucleotide sequence of the Toledo isolate of turnip ringspot
RT virus.";
RL Arch. Virol. 154:1917-1922(2009).
CC -!- FUNCTION: Responsible for viral RNA2 accumulation. May function by
CC recruiting the RNA1-encoded polyprotein that contains the replication
CC protein to RNA2 and enable its replication.
CC {ECO:0000256|ARBA:ARBA00003642}.
CC -!- SUBCELLULAR LOCATION: Host cell junction, host plasmodesma
CC {ECO:0000256|ARBA:ARBA00004621}.
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DR EMBL; FJ712027; ACV41392.1; -; Genomic_RNA.
DR RefSeq; YP_003193666.1; NC_013219.1.
DR GeneID; 11187370; -.
DR KEGG; vg:11187370; -.
DR Proteomes; UP000202412; Genome.
DR GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0039617; C:T=3 icosahedral viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.20; -; 2.
DR InterPro; IPR003181; Como_LCP.
DR InterPro; IPR003182; RNA2_polyprotein.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF02247; Como_LCP; 1.
DR Pfam; PF02248; Como_SCP; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 3.
PE 4: Predicted;
KW Capsid protein {ECO:0000256|ARBA:ARBA00023060};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Host cell junction {ECO:0000256|ARBA:ARBA00023081};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022463};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022463}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Suppressor of RNA silencing {ECO:0000256|ARBA:ARBA00022463};
KW T=3 icosahedral capsid protein {ECO:0000256|ARBA:ARBA00023060};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023031};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00022463};
KW Viral movement protein {ECO:0000256|ARBA:ARBA00023031};
KW Virion {ECO:0000256|ARBA:ARBA00023060}.
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1045..1095
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1087
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1095 AA; 122063 MW; D43F0D71C28ADBB3 CRC64;
MNNIKGRHHC IDNLIPQFAG EPARDFSDKP QEKYVKFLKV SPFSFLCFLI VCHIVTYCET
VFKVCFYFNS WTGTKLRDWL LSITRDANVE YKRLEAISSW SAGHQVVIQH SFSAKKMETV
MERGIAAKAL ELRNDSAMNK GKRFVGLKDH IPAGKDLYVH KQKLFEMLKG SKRSREVDIS
RIKGCEVVEM KHIDVGTLSP GENQIINVKI VKDDMLPQPV QSDYAMVTHS NESKYANAMH
VGAIEVIFNS YASPTSDIVG GMILVDTCHK SVANAVRSVF VTGLAGGKLI RVLMYPNTLV
EIGPKMNDRF KLVCTTSNSD ISEGFNLASV KVNVVGCTQS LMTQYVPQPL LDNLLNKEQG
TVVEYLGQLS YVMHHSNHIT EEFLANQTME FDLGKKLQLT PSGSGASLAK STSMRYVVGP
KQRLLNAEED DGASSFDKRR DAARKIVGMR ADATYVDPVF GMTQRAFGQA STTQSLLNKF
ANTRQMEGTP IETKIARTKI ILTKVMAGGN ILYTERLSDV LSNVEQRAAI AFQRTHVQHK
KLVALATINV PENTGCALMM CYNSGIRGKA VVDAYTASAE ASTIWNPACQ QQARLEINVN
PCKSAWSYQF LRQSKGVFNV VCISGWTTTP STDLSLTIDW YLSDKDAEPE TYCAVGINPK
IVLNRWMGKL SFPQGTDVTL RRMPLAIGGG AGGTGLVYMN MPNALCSLWR YMRGGMSFEV
IKLSSPYIKA TIAFFIAFTD VDATVPNLEA YPHKLVQFSE IQERVTISFD KEDFVMAWST
QVHNSVPLSE DGCPYLYAVV HDSVGSTISG DFNIGVVLKE MNEVESIGRH PGWKGARPLA
VSPQGLRKSP SGVWNELFMV RGPPEAKSTD VVQFAIDLVG VGIATKNPGA WSIETNNSPM
NNLMRTATWK SGTFHFQVLM EGNPLIKRGD WSSYCEVSLT QSTKVSTMSS RNWVMKDPSS
WELEFDIKIE GPNDGFENWE SHFSNQTSWF LVFSVFNPDQ STVFVVNGMI DDDCWFAGNT
LMPPFLEPGS VSSRHSFLSS VQFDYGTTPS RRAPSSPADN EDDDGRRSER IRQLERYRER
DDQNRGNLAT YMRRS
//
