ID   C7XVE6_9LACO            Unreviewed;       437 AA.
AC   C7XVE6;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   SubName: Full=Xanthine permease {ECO:0000313|EMBL:EEU30312.1};
GN   Name=pbuX {ECO:0000313|EMBL:EEU30312.1};
GN   ORFNames=HMPREF0501_00690 {ECO:0000313|EMBL:EEU30312.1};
OS   Limosilactobacillus coleohominis 101-4-CHN.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Limosilactobacillus.
OX   NCBI_TaxID=575594 {ECO:0000313|EMBL:EEU30312.1, ECO:0000313|Proteomes:UP000003987};
RN   [1] {ECO:0000313|EMBL:EEU30312.1, ECO:0000313|Proteomes:UP000003987}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=101-4-CHN {ECO:0000313|EMBL:EEU30312.1,
RC   ECO:0000313|Proteomes:UP000003987};
RG   The Broad Institute Genome Sequencing Platform;
RA   Ward D., Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Liu Y., Xu Q., Lander E., Nusbaum C., Galagan J., Birren B.;
RT   "The Genome Sequence of Lactobacillus coleohominis strain 101-4-CHN.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR   EMBL; GG698803; EEU30312.1; -; Genomic_DNA.
DR   AlphaFoldDB; C7XVE6; -.
DR   STRING; 575594.HMPREF0501_00690; -.
DR   eggNOG; COG2233; Bacteria.
DR   HOGENOM; CLU_017959_8_2_9; -.
DR   OrthoDB; 9805749at2; -.
DR   Proteomes; UP000003987; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR   InterPro; IPR006043; NCS2.
DR   InterPro; IPR017588; UacT-like.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   NCBIfam; TIGR00801; ncs2; 1.
DR   NCBIfam; NF037981; NCS2_1; 1.
DR   NCBIfam; TIGR03173; pbuX; 1.
DR   PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR   PANTHER; PTHR42810:SF4; URIC ACID TRANSPORTER UACT; 1.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003987};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        50..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        74..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        170..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        194..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        229..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        319..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        346..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   437 AA;  46629 MW;  C55CF86A003ED73B CRC64;
     MTQQTTQPAP TANFGKNLIL GFQHLLAMYS GDVLVPLLIG NFLHFSTAQM TYLVSIDIFM
     CGIATLLQLH RTPLMGIGLP VVLGCAVQSV APLESIGSKM GITYMYGAII CAGIFIFLIA
     GYFAKMKKLF PPVVTGSLIT VIGFTLVPVG FQNLGGGTAT AKSFGSPQDL IIGFLTIIVI
     VLINRFGKGF IKSIAILLGI LIGSFAAAAW GMVSTQPVTS AAWFHLPRFF YFGVPTFNSG
     AIITMILVAL TTMIESTGVY FALAEATHQK ITENDMKRGY RAEGIAAILG GLFNTFPYST
     FSQNVGVLKM SGVRSRRPVY YAAVLLLILG LLPKAGALAT MIPDPVLGGA MVVMFGMVGI
     QGMQILHKVD FSKNSNLMVA SLSIGLGLGV TVYPQIFQHL NTELQIILGN GVVMGSLAAV
     ILNLILNFDE FKSSTKD
//