ID   C8B7S8_9HIV1            Unreviewed;       210 AA.
AC   C8B7S8;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:ACV14531.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:ACV14531.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:ACV14531.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:ACV14531.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CA53376 {ECO:0000313|EMBL:ACV14531.1};
RA   Shahriar R., Rhee S.-Y., Liu T.F., Fessel W.J., Scarsella A., Towner W.,
RA   Holmes S.P., Zolopa A.R., Shafer R.W.;
RT   "Nonpolymorphic HIV-1 Protease and RT Treatment-Selected Mutations.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GQ209584; ACV14531.1; -; Genomic_RNA.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF5; RIBONUCLEASE H; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW   ECO:0000313|EMBL:ACV14531.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          7..197
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACV14531.1"
FT   NON_TER         210
FT                   /evidence="ECO:0000313|EMBL:ACV14531.1"
SQ   SEQUENCE   210 AA;  24504 MW;  D78C3CB40EFA5BDF CRC64;
     CTEMEKEGKI SKIGPENPYN TPVFAIKKKD STKWRKLVDF RELNKRTQDF WEVQLGIPHP
     AGLKKKKSVT VLDVGDAYFS VPLDEDFRKY TAFTIPSINN ETPGIRYQYN VLPQGWKGSP
     AIFQXSMTKI LEPFRKQNPD IVIYQYVDDL YVGSDLEIGQ HRTKVEELRG HLLRWGFTTP
     DKKHQKEPPF LWMGYELHPD KWTVQPIVLP
//