ID C8C503_9ENTO Unreviewed; 860 AA.
AC C8C503;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE Flags: Fragment;
OS Echovirus E30.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Ensavirinae; Enterovirus; Enterovirus B.
OX NCBI_TaxID=41846 {ECO:0000313|EMBL:ACV04426.1};
RN [1] {ECO:0000313|EMBL:ACV04426.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E30-W19016/BLR/1997 {ECO:0000313|EMBL:ACV04426.1};
RA Dziadziulia K.L., Amvrosieva T.V., Paklonskaya N.V., Biazruchka A.,
RA Bohush Z.F., Kazinetz O.N.;
RT "Potential cardiovirulence determinants of the Enteroviruses causing
RT myocarditis.";
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of immature procapsids, which is cleaved into
CC capsid proteins VP4 and VP2 after maturation (By similarity). Allows
CC the capsid to remain inactive before the maturation step.
CC {ECO:0000256|ARBA:ARBA00025202}.
CC -!- SUBUNIT: Interacts with capsid protein VP1 and capsid protein VP3 to
CC form heterotrimeric protomers. {ECO:0000256|ARBA:ARBA00011474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Virion
CC {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the picornaviruses polyprotein family.
CC {ECO:0000256|ARBA:ARBA00008303}.
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DR EMBL; GQ370507; ACV04426.1; -; Genomic_RNA.
DR MEROPS; N08.001; -.
DR GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0044694; P:pore-mediated entry of viral genome into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR CDD; cd00205; rhv_like; 3.
DR Gene3D; 2.60.120.20; -; 3.
DR Gene3D; 4.10.80.10; Picornavirus coat protein VP4; 1.
DR InterPro; IPR003138; Pico_P1A.
DR InterPro; IPR036988; Pico_P1A_sf.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF02226; Pico_P1A; 1.
DR Pfam; PF00073; Rhv; 3.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 2.
PE 3: Inferred from homology;
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023247};
KW Eukaryotic host translation shutoff by virus
KW {ECO:0000256|ARBA:ARBA00022809};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Pore-mediated penetration of viral genome into host cell
KW {ECO:0000256|ARBA:ARBA00023255};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW Virion {ECO:0000256|ARBA:ARBA00022561};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 93..299
FT /note="Picornavirus capsid"
FT /evidence="ECO:0000259|Pfam:PF00073"
FT DOMAIN 359..524
FT /note="Picornavirus capsid"
FT /evidence="ECO:0000259|Pfam:PF00073"
FT DOMAIN 613..783
FT /note="Picornavirus capsid"
FT /evidence="ECO:0000259|Pfam:PF00073"
FT NON_TER 860
FT /evidence="ECO:0000313|EMBL:ACV04426.1"
SQ SEQUENCE 860 AA; 95515 MW; 1B82472D5B7699D2 CRC64;
MGAQVSTQKT GAHETGLSAS GNSIIHYTNI NYYKDSASNS LNRQDFTQDP SKFTEPVKDV
MIKTLPALNS PTVEECGYSD RVRSITLGNS TITTQECANV VVGYGVWPTY LSDHEATAVD
QPTQPDVATC RFYTLESVKW ESSSAGWCWK FPEALSDMGL FGQNMQYHYL GRTGYTIHVQ
CNASKFHQGC LLVACVPEAE MGAATTDHAM NHTKLSNIGQ AMEFSAEKST DQTGPQTAVH
NAGMGVAVGN LTIFPHQWIN LRTNNSATIV MPYINSVPMD NMYRHYNFTL MVIPFAKLEH
SPQASTYVSI TVTVAPMCAE YNTLRLAGHQ GLPTMNTPGS TQFLTSDDFQ SPSAMPQFDV
TPEIQIPGQV RNLMEIAEVD SVVPVNNTEE HVNSMEAYRI PVRPQTSSGE QVFGFQLQPG
HDSVLKHTLL GEILNYYANW SGSMKLTFMY CGAAMATGKF LIAYSPPGAG VPGSRKDAML
GTHVIWDVGL QSSCVLCVPW ISQTNYRYVT SDAYTDAGYI TCWYQTSIVT PPDIPTTSTI
LCFVSACNDF SVRLLRDPPF ITQQALYQND PESALNRAVG RVADTIASGP VNTEQIPALT
AVETGHTSQV VPSDTMQTRH VVNYHTRSES SIENFMGRAA CVYIAQYATE KVNDELDRYT
NWEITTRQVA QLRRKLEMFT YMRFDLEITF VITSSQRTST TYASDSPPLT HQVMYVPPGG
PIPRSYEDFA WQTSTNPSVF WTEGNAPPRM SIPFMSVGNA YCNFYDGWSH FSQSGVYGYT
TLNNMGHLYF RHVNKSTAYP VNSVARVYFK PKHVKAWVPR APRLCPYLYA RNVNFNVQGV
TESRGKITLD RSTHNPLSNT
//
