ID   C8KGI1_MUSSB            Unreviewed;       396 AA.
AC   C8KGI1;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE   Flags: Fragment;
GN   Name=vwf {ECO:0000313|EMBL:BAI39577.1};
OS   Mustela sibirica (Siberian weasel).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=36240 {ECO:0000313|EMBL:BAI39577.1};
RN   [1] {ECO:0000313|EMBL:BAI39577.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=TH98 {ECO:0000313|EMBL:BAI39577.1};
RX   PubMed=19699810; DOI=10.1016/j.ympev.2009.08.019;
RA   Sato J.J., Wolsan M., Minami S., Hosoda T., Sinaga M.H., Hiyama K.,
RA   Yamaguchi T., Suzuki H.;
RT   "Deciphering and dating the red panda's ancestry and early adaptive
RT   radiation of Musteloidea.";
RL   Mol. Phylogenet. Evol. 53:907-922(2009).
CC   -!- SUBUNIT: Multimeric. Interacts with F8.
CC       {ECO:0000256|ARBA:ARBA00025858}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR   EMBL; AB285412; BAI39577.1; -; Genomic_DNA.
DR   AlphaFoldDB; C8KGI1; -.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   CDD; cd01450; vWFA_subfamily_ECM; 2.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR   InterPro; IPR032361; VWA_N2.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR   PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR   Pfam; PF00092; VWA; 2.
DR   Pfam; PF16164; VWA_N2; 1.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00327; VWA; 2.
DR   SUPFAM; SSF53300; vWA-like; 2.
DR   PROSITE; PS50234; VWFA; 2.
PE   4: Predicted;
KW   Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          33..209
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          254..396
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAI39577.1"
FT   NON_TER         396
FT                   /evidence="ECO:0000313|EMBL:BAI39577.1"
SQ   SEQUENCE   396 AA;  44254 MW;  C7EE353DCDA8BA7C CRC64;
     VPPTEGPVGS PTPYVEDTPE PPLHDFYCSR LLDLVFLLDG SSKLSEGEFQ VLKVFVVGMM
     ERLHISQKRI RVAVVEYHDG SHAYLELQDR KRPSELRRIA SQVRYVGSEV ASTSEVLKYT
     LFQIFGKIDR PEASRIALLL MASQEPPKLA RNLVRYVQGL KKKKVIVIPV GIGPHVNLKQ
     IRNIEKQAPE NKAFVLSGVD ELEQRRDEII SYLCDLAPEA PRPTQQPPVL PVTVGPELLG
     APSSGPRRNS MVLDVVFILE GSDKIGEANF NKSRDFMEEV IRRMDVSQDG VHVTVLQYSY
     AVAVEYTFSK AQSKGEVLQH VREIRFRGGN RTNTGLALQY LSEHSFSVNQ GDREQVPNLV
     YMVTGNPASD EIKRMPGDIQ VVPIGVGPHA NPQELE
//