ID C8PAI4_9LACO Unreviewed; 443 AA.
AC C8PAI4;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE SubName: Full=Peptidase T {ECO:0000313|EMBL:EEW52473.1};
DE EC=3.4.11.- {ECO:0000313|EMBL:EEW52473.1};
GN Name=pepT {ECO:0000313|EMBL:EEW52473.1};
GN ORFNames=HMPREF0520_0104 {ECO:0000313|EMBL:EEW52473.1};
OS Lactobacillus iners DSM 13335.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=525328 {ECO:0000313|EMBL:EEW52473.1, ECO:0000313|Proteomes:UP000004115};
RN [1] {ECO:0000313|EMBL:EEW52473.1, ECO:0000313|Proteomes:UP000004115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13335 {ECO:0000313|EMBL:EEW52473.1,
RC ECO:0000313|Proteomes:UP000004115};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR037215-2};
CC Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000256|PIRSR:PIRSR037215-
CC 2};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEW52473.1}.
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DR EMBL; ACLN01000003; EEW52473.1; -; Genomic_DNA.
DR AlphaFoldDB; C8PAI4; -.
DR HOGENOM; CLU_053676_0_0_9; -.
DR Proteomes; UP000004115; Unassembled WGS sequence.
DR GO; GO:0045148; F:tripeptide aminopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006518; P:peptide metabolic process; IEA:InterPro.
DR CDD; cd03892; M20_peptT; 1.
DR Gene3D; 3.30.70.360; -; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR036264; Bact_exopeptidase_dim_dom.
DR InterPro; IPR002933; Peptidase_M20.
DR InterPro; IPR011650; Peptidase_M20_dimer.
DR InterPro; IPR010161; Peptidase_M20B.
DR NCBIfam; TIGR01882; peptidase-T; 1.
DR PANTHER; PTHR42994; PEPTIDASE T; 1.
DR PANTHER; PTHR42994:SF1; PEPTIDASE T; 1.
DR Pfam; PF07687; M20_dimer; 1.
DR Pfam; PF01546; Peptidase_M20; 1.
DR PIRSF; PIRSF037215; Peptidase_M20B; 1.
DR SUPFAM; SSF55031; Bacterial exopeptidase dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 4: Predicted;
KW Aminopeptidase {ECO:0000313|EMBL:EEW52473.1};
KW Hydrolase {ECO:0000313|EMBL:EEW52473.1};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR037215-2};
KW Protease {ECO:0000313|EMBL:EEW52473.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004115};
KW Zinc {ECO:0000256|PIRSR:PIRSR037215-2}.
FT DOMAIN 238..335
FT /note="Peptidase M20 dimerisation"
FT /evidence="ECO:0000259|Pfam:PF07687"
FT ACT_SITE 111
FT /evidence="ECO:0000256|PIRSR:PIRSR037215-1"
FT ACT_SITE 205
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR037215-1"
FT BINDING 109
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR037215-2"
FT BINDING 171
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR037215-2"
FT BINDING 171
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR037215-2"
FT BINDING 206
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR037215-2"
FT BINDING 228
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR037215-2"
FT BINDING 410
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR037215-2"
SQ SEQUENCE 443 AA; 50635 MW; B9E1729F4373157C CRC64;
MQIVLFLLWF QKLILILFRT YFKKVGVYIM EYPTLLPRFL KYVKINSRSD ENSQRFPSTE
IEEKFQKIIL NDLKELGLQC YYNQKSGCVI ATIDSNVDYD VPTFGLLAHC DTADFESNNI
NPQITHKYDG VSKIKLGDTD FYLDPAIFPH LKKYKGQTII STSGDTLLGG DDKCGVSELL
TFAEYLVNHP EEKHGEIKLA FTPDEEIGTG ASHFDVEDFG AKFAYTVDGE GPGKLDWGTF
SAAQFSLDIQ GIDVHPAQAK DKMINAIKLA IDFQNQLPQN EVPEKTAGEE GFYHLLKFEG
TVDHAHLEYI IRDFKRDNLE KRKELVQNIV NKINDQFDQK RVVLKMADQY YNMADELKKN
MEVVDLARNA YKALGLTINE DPVRGGTDGS QLTYMGLPCP NLFAGEENMH GRYEYTVLES
MWLAVDVLRK INELHLKKYQ KLI
//