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Database: UniProt
Entry: C8PKQ3_9PROT
LinkDB: C8PKQ3_9PROT
Original site: C8PKQ3_9PROT 
ID   C8PKQ3_9PROT            Unreviewed;       442 AA.
AC   C8PKQ3;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   25-OCT-2017, entry version 52.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EEV16662.1};
GN   ORFNames=CAMGR0001_0275 {ECO:0000313|EMBL:EEV16662.1};
OS   Campylobacter gracilis RM3268.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=553220 {ECO:0000313|EMBL:EEV16662.1, ECO:0000313|Proteomes:UP000005709};
RN   [1] {ECO:0000313|EMBL:EEV16662.1, ECO:0000313|Proteomes:UP000005709}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RM3268 {ECO:0000313|EMBL:EEV16662.1,
RC   ECO:0000313|Proteomes:UP000005709};
RA   Madupu R., Sebastian Y., Durkin A.S., Torralba M., Methe B.,
RA   Sutton G.G., Strausberg R.L., Nelson K.E.;
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EEV16662.1}.
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DR   EMBL; ACYG01000030; EEV16662.1; -; Genomic_DNA.
DR   RefSeq; WP_005872941.1; NZ_ACYG01000030.1.
DR   ProteinModelPortal; C8PKQ3; -.
DR   STRING; 553220.CAMGR0001_0275; -.
DR   EnsemblBacteria; EEV16662; EEV16662; CAMGR0001_0275.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000005709; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005709};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005709}.
FT   DOMAIN      135    261       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      344    413       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     143    150       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   442 AA;  50742 MW;  73DFDAEB26C1D413 CRC64;
     MATSQAQEIL SNLEKEILPT EYSRYIKNLK FNDKNSTPEF FIYNATNEFI AKYTQTKYGT
     KIKELIKKQF GLNDVIVKIT SKAKISPKEK VKIISEKPKS TILSENYNFE NFIIGDSNKF
     AFECSVSVAK EPGIRFNPLF IYGPSGLGKT HLLQSIGNYC IKKGKTVICV TSEQFANDFV
     FNLKNNSIDK FKQKYRNCDV LLIDDIQFLI GRDKAQEELF YTFNELKDKN CQIVLTNDLP
     PKFLKGFENR LTTRFESGII ANITPPNLET KIAIINKKSE ENRVRIPHDV VEYIAANMGD
     NIREIEGAIN KLNAYSSILR TKITLEFTKS TLQDQIHQKY SSVSLEHVIE VISKELNVKP
     SELKSKTRAK NVVEARQICI YLTKQLTQNS MPKIAAFFNL KDHSAISKNI KKINELIQTD
     EMLKIKIEEL KNKITKKDKN EI
//
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