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Database: UniProt
Entry: C8PZ52_9PROT
LinkDB: C8PZ52_9PROT
Original site: C8PZ52_9PROT 
ID   C8PZ52_9PROT            Unreviewed;       446 AA.
AC   C8PZ52;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   05-JUL-2017, entry version 51.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EEV22502.1};
GN   ORFNames=ENHAE0001_0396 {ECO:0000313|EMBL:EEV22502.1};
OS   Enhydrobacter aerosaccus SK60.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   unclassified Rhodospirillales; Enhydrobacter.
OX   NCBI_TaxID=553217 {ECO:0000313|EMBL:EEV22502.1, ECO:0000313|Proteomes:UP000010294};
RN   [1] {ECO:0000313|EMBL:EEV22502.1, ECO:0000313|Proteomes:UP000010294}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK60 {ECO:0000313|EMBL:EEV22502.1,
RC   ECO:0000313|Proteomes:UP000010294};
RA   Madupu R., Yinong S., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA   Strausberg R.L., Nelson K.E.;
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EEV22502.1}.
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DR   EMBL; ACYI01000059; EEV22502.1; -; Genomic_DNA.
DR   RefSeq; WP_007116624.1; NZ_ACYI01000059.1.
DR   ProteinModelPortal; C8PZ52; -.
DR   STRING; 553217.ENHAE0001_0396; -.
DR   EnsemblBacteria; EEV22502; EEV22502; ENHAE0001_0396.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000010294; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010294};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010294}.
FT   DOMAIN      145    271       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      354    423       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     153    160       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   446 AA;  50945 MW;  1204BAA3A97FBEC7 CRC64;
     MADALWLKCV DELKYQVPDN IFTMWIRPLS ASMHNNTMVV NVPNQYFASY VEKNHLSQIQ
     TILQQLEPTL PIQVQIQIDK GNAITDAVSK QEFGEQKVTL VKTEQQRSFQ YIDPHFTFDQ
     FVTAKSNQIA YSICRETANN LGQSKNNPLF IYGATGLGKT HLMQAIAHEI LKQGKSFYYF
     TSDKFVNQLV HSLRTQKIDE FKDKIKKADL LIIDDIHVIA GKQKSSEQFL LLLNDFMSKN
     KQVILASDKH PSALTDFDER LKSRLAWGVA VALEPPELET RIQILQKKSK AQEVILPKEC
     AIFIAQHIIA NVRELEGALN KVLAISRLLN QPIHLELVQM ALKDLIAMRV QAVSMDNIRK
     VVAEFYDISV KDLMGKKRLR HIARPRQVAM SLARELTNNS FTEIGQSFGG RDHTTVMHAC
     EKVQELCVSD LMFDKDYRSL KLMLQT
//
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