ID C8W323_DESAS Unreviewed; 445 AA.
AC C8W323;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=site-specific DNA-methyltransferase (cytosine-N(4)-specific) {ECO:0000256|ARBA:ARBA00012185};
DE EC=2.1.1.113 {ECO:0000256|ARBA:ARBA00012185};
GN OrderedLocusNames=Dtox_0894 {ECO:0000313|EMBL:ACV61790.1};
OS Desulfofarcimen acetoxidans (strain ATCC 49208 / DSM 771 / KCTC 5769 / VKM
OS B-1644 / 5575) (Desulfotomaculum acetoxidans).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptococcaceae;
OC Desulfofarcimen.
OX NCBI_TaxID=485916 {ECO:0000313|EMBL:ACV61790.1, ECO:0000313|Proteomes:UP000002217};
RN [1] {ECO:0000313|EMBL:ACV61790.1, ECO:0000313|Proteomes:UP000002217}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49208 / DSM 771 / VKM B-1644
RC {ECO:0000313|Proteomes:UP000002217};
RX PubMed=21304664; DOI=10.4056/sigs.39508;
RA Spring S., Lapidus A., Schroder M., Gleim D., Sims D., Meincke L.,
RA Glavina Del Rio T., Tice H., Copeland A., Cheng J.F., Lucas S., Chen F.,
RA Nolan M., Bruce D., Goodwin L., Pitluck S., Ivanova N., Mavromatis K.,
RA Mikhailova N., Pati A., Chen A., Palaniappan K., Land M., Hauser L.,
RA Chang Y.J., Jeffries C.D., Chain P., Saunders E., Brettin T., Detter J.C.,
RA Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P., Han C.;
RT "Complete genome sequence of Desulfotomaculum acetoxidans type strain
RT (5575).";
RL Stand. Genomic Sci. 1:242-253(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:16857, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:13674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:137933; EC=2.1.1.113;
CC Evidence={ECO:0000256|ARBA:ARBA00001893};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family. N(4)
CC subfamily. {ECO:0000256|ARBA:ARBA00010203}.
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DR EMBL; CP001720; ACV61790.1; -; Genomic_DNA.
DR RefSeq; WP_015756506.1; NC_013216.1.
DR AlphaFoldDB; C8W323; -.
DR STRING; 485916.Dtox_0894; -.
DR REBASE; 21988; M.DacORF894P.
DR KEGG; dae:Dtox_0894; -.
DR eggNOG; COG0863; Bacteria.
DR HOGENOM; CLU_027633_0_0_9; -.
DR OrthoDB; 9800801at2; -.
DR Proteomes; UP000002217; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0015667; F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR017985; MeTrfase_CN4_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00093; N4_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002217};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 445 AA; 50913 MW; 391251CB9273B329 CRC64;
MSLLDPEKNK RSEDKVVYRK ILTGEATFRG GLISPFHRWF RLTPSYGPEL VEIMLAETET
CDKHVVLDPF AGGGTTLIQC KLNQIAAYGF EINPMLHFNC RVSTNWQLNA SLLRKNLENL
SSFYFEKKLA LKNAEVEETG IRLPAIHNIF RWWRKDVLKD LLVLKLAITT ARMDEPERNF
FLLGLAGVLV PDLTNVTLGR LQLHFVDKTG RDIEVWSTFS NHIEEMLSDL ESTGSKVANT
PSTVFMTDST HLEGIDIPQK IDRVITSPPY PNRYSYVWNT RPHLYFFDFL SNSKQAADLD
KITIGGTWGS ATSILNKGVI DPLYPIINQK VSPIAGQIRE QDNLMANYIT KYFNMLAKQI
VAQDRFLSDY ARCAYVVGCS RIKGIFIETD KILGEIFEGL DLGYQIHKIE RIRKRHSDKD
LHEAIVYVYK GCRKQNKKQY SISSN
//
