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Database: UniProt
Entry: C8W8K4_ATOPD
LinkDB: C8W8K4_ATOPD
Original site: C8W8K4_ATOPD 
ID   C8W8K4_ATOPD            Unreviewed;       509 AA.
AC   C8W8K4;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   05-JUL-2017, entry version 64.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   OrderedLocusNames=Apar_0002 {ECO:0000313|EMBL:ACV50442.1};
OS   Atopobium parvulum (strain ATCC 33793 / DSM 20469 / JCM 10300 / VPI
OS   0546) (Streptococcus parvulus) (Peptostreptococcus parvulus).
OC   Bacteria; Actinobacteria; Coriobacteriia; Coriobacteriales;
OC   Atopobiaceae; Atopobium.
OX   NCBI_TaxID=521095 {ECO:0000313|EMBL:ACV50442.1, ECO:0000313|Proteomes:UP000000960};
RN   [1] {ECO:0000313|EMBL:ACV50442.1, ECO:0000313|Proteomes:UP000000960}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33793 / DSM 20469 / JCM 10300 / VPI 0546
RC   {ECO:0000313|Proteomes:UP000000960};
RX   PubMed=21304653; DOI=10.4056/sigs.29547;
RA   Copeland A., Sikorski J., Lapidus A., Nolan M., Del Rio T.G.,
RA   Lucas S., Chen F., Tice H., Pitluck S., Cheng J.F., Pukall R.,
RA   Chertkov O., Brettin T., Han C., Detter J.C., Kuske C., Bruce D.,
RA   Goodwin L., Ivanova N., Mavromatis K., Mikhailova N., Chen A.,
RA   Palaniappan K., Chain P., Rohde M., Goker M., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Detter J.C.;
RT   "Complete genome sequence of Atopobium parvulum type strain (IPP
RT   1246).";
RL   Stand. Genomic Sci. 1:166-173(2009).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP001721; ACV50442.1; -; Genomic_DNA.
DR   RefSeq; WP_012808102.1; NC_013203.1.
DR   ProteinModelPortal; C8W8K4; -.
DR   STRING; 521095.Apar_0002; -.
DR   EnsemblBacteria; ACV50442; ACV50442; Apar_0002.
DR   KEGG; apv:Apar_0002; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000101250; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000000960; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000960};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000960}.
FT   DOMAIN      184    326       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      415    484       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     192    199       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      116    140       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   509 AA;  57327 MW;  C09621AEF3FF08FD CRC64;
     MDASIDSDAI ALWQDAIDLL VEENQPEAFI AMLRTCTPIK VEDDTLYAET SMRLAYNRIL
     KNLPIVERCL SAAAFEDVIL SLTLTKSSTP VTTTSTMTPQ EFNAWKQKTT PIQAVVPEQI
     QDFESQEQSL EELKQQTLKR RKSNPLYEET SFNSNLTFDR FVVGDENELA HQHALNVAND
     AKGKANPLFI YGASGLGKTH LLRAVQNYIN SEDIERVCVY KDADAFVDDY VNAVRKNASG
     NAATELNNNY QNIDVLIIDD VQKLAGKAGT INFFFNIFNS LIDRGKQIIL AADRTPAQLG
     MGSDGFDDRI TSRMSGGIVI GIESPSYEMK LNLIHVFCDR AFKERNSSLS VDDMPEEISR
     YMADKAGQSI RTLEGFCNRC VTGQIKAKES GKNIKQEEID KIADTLWRRV SKTVNIEKVQ
     EVVENIYGIN HRDIVGNKRN KEIAEPRHVA IYLAHDLCQY TLVNIGKHFG GRKHATILHS
     IEVIEEKIKE DKSFYDQISQ LKKTILEQS
//
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