ID C8XT87_9BACT Unreviewed; 452 AA.
AC C8XT87;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 03-MAY-2023, entry version 40.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
OS uncultured bacterium RM57.
OC Bacteria; environmental samples.
OX NCBI_TaxID=561246 {ECO:0000313|EMBL:ACI04480.1};
RN [1] {ECO:0000313|EMBL:ACI04480.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19146479;
RA Craig J.W., Chang F.Y., Brady S.F.;
RT "Natural products from environmental DNA hosted in Ralstonia
RT metallidurans.";
RL ACS Chem. Biol. 4:23-28(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; FJ151552; ACI04480.1; -; Genomic_DNA.
DR AlphaFoldDB; C8XT87; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR PANTHER; PTHR34220; SENSOR HISTIDINE KINASE YPDA; 1.
DR PANTHER; PTHR34220:SF7; SENSOR HISTIDINE KINASE YPDA; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF06580; His_kinase; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:ACI04480.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000313|EMBL:ACI04480.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 332..435
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 452 AA; 50043 MW; 804A7D19A8DE1E44 CRC64;
MHAIDSKLIL ITLLVELGVA AALASSLARS TSFKRLLLET NRSRAETLRL AAWICIPLML
GVLVRVRVPN FLAADLSFEA TVLLALLLGP FPAVAGGAAL ALPALLHREF FALPVNVGVA
LLFGYFRRFV DEEDVWSFSP LIDLSVYRWV RRAFTSSLLD RQISLLVLLM AVQFVTSMLA
HFHPHYYFEL SSDSWVIELA ICACAPVVVG IPLKIWNAVR IEQKFEEQSR LLLEARLDAL
RRQINPHFLF NTLNSIASLV RSQPELAREM IVKLGNILRT LLRDHDAFVP LGEELAFTDD
YLDIEVVRFG SKLRVVKEIA EDTLDMEVPS MLLQPLIENS IKHGLEPRIS GGTVTLRSRA
AQGQLIIEVE DDGVGAEPGR AVTAPMSGLV REGTGIGMRN VRERMQVLYG DAAEVEMVSR
PGRGTKVRLV IPTGNLEEPT AARQRTSLEP AG
//
