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Database: UniProt
Entry: C99L2_RAT
LinkDB: C99L2_RAT
Original site: C99L2_RAT 
ID   C99L2_RAT               Reviewed;         246 AA.
AC   Q8R1R5; Q9JJL7;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   27-MAR-2024, entry version 101.
DE   RecName: Full=CD99 antigen-like protein 2;
DE   AltName: Full=MIC2-like protein 1;
DE   AltName: Full=Rhombencephalic expression protein 40 kDa;
DE            Short=Protein rhombex-40;
DE   AltName: CD_antigen=CD99;
DE   Flags: Precursor;
GN   Name=Cd99l2; Synonyms=Mic2l1, Rhombex40;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Brain;
RX   PubMed=10834302; DOI=10.1016/s0024-3205(00)00545-2;
RA   Shimokawa N., Jingu H., Okada J., Miura M.;
RT   "Molecular cloning of Rhombex-40 a transmembrane protein from the ventral
RT   medullary surface of the rat brain by differential display.";
RL   Life Sci. 66:2183-2191(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Lewis; TISSUE=Thymus;
RX   PubMed=12706889; DOI=10.1016/s0378-1119(03)00401-3;
RA   Suh Y.H., Shin Y.K., Kook M.-C., Oh K.I., Park W.S., Kim S.H., Lee I.-S.,
RA   Park H.J., Huh T.-L., Park S.H.;
RT   "Cloning, genomic organization, alternative transcripts and expression
RT   analysis of CD99L2, a novel paralog of human CD99, and identification of
RT   evolutionary conserved motifs.";
RL   Gene 307:63-76(2003).
CC   -!- FUNCTION: Plays a role in a late step of leukocyte extravasation
CC       helping cells to overcome the endothelial basement membrane. Acts at
CC       the same site as, but independently of, PECAM1 (By similarity).
CC       Homophilic adhesion molecule, but these interactions may not be
CC       required for cell aggregation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell
CC       junction {ECO:0000250}. Secreted {ECO:0000250|UniProtKB:Q8TCZ2}.
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in the ventral medullary
CC       surface of the brain, moderate expression in the cerebral cortex and
CC       cerebellum. Low expression in lung and kidney. No expression in heart,
CC       stomach, intestine and skeletal muscle.
CC   -!- PTM: O-glycosylated. {ECO:0000250|UniProtKB:Q8TCZ2}.
CC   -!- SIMILARITY: Belongs to the CD99 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA90767.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AB031014; BAA90767.1; ALT_FRAME; mRNA.
DR   EMBL; AF481858; AAL89685.1; -; mRNA.
DR   RefSeq; NP_604454.1; NM_134459.1.
DR   RefSeq; XP_006251738.1; XM_006251676.3.
DR   RefSeq; XP_008768818.1; XM_008770596.2.
DR   RefSeq; XP_017443944.1; XM_017588455.1.
DR   AlphaFoldDB; Q8R1R5; -.
DR   STRING; 10116.ENSRNOP00000024427; -.
DR   GlyGen; Q8R1R5; 1 site.
DR   PhosphoSitePlus; Q8R1R5; -.
DR   SwissPalm; Q8R1R5; -.
DR   PaxDb; 10116-ENSRNOP00000024427; -.
DR   Ensembl; ENSRNOT00055033885; ENSRNOP00055027520; ENSRNOG00055019830.
DR   Ensembl; ENSRNOT00060018884; ENSRNOP00060014719; ENSRNOG00060011178.
DR   Ensembl; ENSRNOT00065019111; ENSRNOP00065014621; ENSRNOG00065011762.
DR   UCSC; RGD:620896; rat.
DR   AGR; RGD:620896; -.
DR   RGD; 620896; Cd99l2.
DR   eggNOG; ENOG502RZ6C; Eukaryota.
DR   HOGENOM; CLU_092825_0_1_1; -.
DR   InParanoid; Q8R1R5; -.
DR   PhylomeDB; Q8R1R5; -.
DR   TreeFam; TF332323; -.
DR   PRO; PR:Q8R1R5; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000018148; Expressed in ovary and 14 other cell types or tissues.
DR   ExpressionAtlas; Q8R1R5; baseline and differential.
DR   Genevisible; Q8R1R5; RN.
DR   GO; GO:0005912; C:adherens junction; ISO:RGD.
DR   GO; GO:0009986; C:cell surface; ISO:RGD.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0050904; P:diapedesis; ISO:RGD.
DR   GO; GO:0034109; P:homotypic cell-cell adhesion; ISO:RGD.
DR   GO; GO:2000391; P:positive regulation of neutrophil extravasation; ISO:RGD.
DR   GO; GO:2000409; P:positive regulation of T cell extravasation; ISO:RGD.
DR   InterPro; IPR022078; CD99L2.
DR   PANTHER; PTHR15076:SF12; CD99 ANTIGEN-LIKE PROTEIN 2; 1.
DR   PANTHER; PTHR15076; CD99/MIC2 PROTEIN RELATED; 1.
DR   Pfam; PF12301; CD99L2; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Cell junction; Cell membrane; Glycoprotein; Membrane;
KW   Proteoglycan; Reference proteome; Secreted; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..246
FT                   /note="CD99 antigen-like protein 2"
FT                   /id="PRO_0000340095"
FT   TOPO_DOM        26..160
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        182..246
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          43..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          223..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..82
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        153
FT                   /note="O-linked (Xyl...) (chondroitin sulfate) serine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TCZ2"
SQ   SEQUENCE   246 AA;  26074 MW;  D4188C2C0DF11FE4 CRC64;
     MVARLTTLLV CLVFSLATLV QRGYGDFDDF NLEDALKETS SVKQSHFSTT TRRTGTTRAP
     ANPAERWDHM TTTTTKRPGT TRAPSNPLEL DGFDLEDALD DRNDLDGPKK PSTGEGGGLS
     DKDLEDILGG GGYKPDKNKG GGGGYGSQDD PGSGAVTDPG TIAGLVSALA AALLGAVSGY
     LSYQHRKFCF SVQRGLDAAY VKGENLEAVV CEEPRVEAAM CEAPPVTDST QHSQPTEPLA
     PERPRI
//
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