ID   C9D9L8_9NEOB            Unreviewed;       203 AA.
AC   C9D9L8;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE            Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE   Flags: Fragment;
OS   Kurixalus odontotarsus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Rhacophoridae; Rhacophorinae;
OC   Kurixalus.
OX   NCBI_TaxID=311825 {ECO:0000313|EMBL:ACV65042.1};
RN   [1] {ECO:0000313|EMBL:ACV65042.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19616637; DOI=10.1016/j.ympev.2009.06.023;
RA   Li J.T., Che J., Murphy R.W., Zhao H., Zhao E.M., Rao D.Q., Zhang Y.P.;
RT   "New insights to the molecular phylogenetics and generic assessment in the
RT   Rhacophoridae (Amphibia: Anura) based on five nuclear and three
RT   mitochondrial genes, with comments on the evolution of reproduction.";
RL   Mol. Phylogenet. Evol. 53:509-522(2009).
RN   [2] {ECO:0000313|EMBL:ACV65042.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Li J., Zhang Y.;
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC       located either in the central nervous system or directly connected to
CC       it. {ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR   EMBL; GQ285687; ACV65042.1; -; Genomic_DNA.
DR   AlphaFoldDB; C9D9L8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|RuleBase:RU364086}.
FT   DOMAIN          110..201
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACV65042.1"
FT   NON_TER         203
FT                   /evidence="ECO:0000313|EMBL:ACV65042.1"
SQ   SEQUENCE   203 AA;  22860 MW;  DD74F2F9F72463BD CRC64;
     ASVRGQSGLA YPGLRTHGTL ENIGGPMSGS RGGLPSLTDT FEQVIEELLE EEQTIRQSEE
     NKDSDMYSSR VMLSTQVPLE PPLLFLLEEY KNYLDAANMS MRVRRHSDPA RRGELSVCDS
     ISEWVTAADK KTAVDMTGQT VTVLEKVPVP KGQLKQYFYE TKCNPMGYMK DGCRGIDKRY
     WNSQCRTTQS YVRALTMDSK KKV
//