ID C9DTE9_9HIV1 Unreviewed; 215 AA.
AC C9DTE9;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ACV66667.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ACV66667.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ACV66667.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACV66667.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PACT1059_subject 15_wk_72_RT8 {ECO:0000313|EMBL:ACV66667.1};
RX PubMed=19605490; DOI=10.1128/JVI.00570-09;
RG Pediatric AIDS Clinical Trials Group P1059 Team;
RA Shiu C., Cunningham C.K., Greenough T., Muresan P., Sanchez-Merino V.,
RA Carey V., Jackson J.B., Ziemniak C., Fox L., Belzer M., Ray S.C.,
RA Luzuriaga K., Persaud D.;
RT "Identification of ongoing human immunodeficiency virus type 1 (HIV-1)
RT replication in residual viremia during recombinant HIV-1 poxvirus
RT immunizations in patients with clinically undetectable viral loads on
RT durable suppressive highly active antiretroviral therapy.";
RL J. Virol. 83:9731-9742(2009).
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DR EMBL; GQ428914; ACV66667.1; -; Genomic_RNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 24..214
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACV66667.1"
FT NON_TER 215
FT /evidence="ECO:0000313|EMBL:ACV66667.1"
SQ SEQUENCE 215 AA; 25158 MW; 2CEFC8A44B2E08C6 CRC64;
VKQWPLTEEK IKALVEICTE MEKEGKISKI GPENPYNTPV FAIKKKDSTK WRKLVDFREL
NKRTQDFWEV QLGIPHPAGL KKKKSVTVLD VGDAYFSVPL DKEFRKYTAF TIPSTNNETP
GIRYQYNVLP QGWKGSPAIF QSSMTKILEP FREQNPDIVI YQYMDDLYVG SDLEIGQHRI
KIEELRAHLL KWGFTTPDKK HQKEPPFLWM GYELH
//
