ID   C9E4P5_VIBCL            Unreviewed;      1246 AA.
AC   C9E4P5;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=ICEVCHBAN5_0036 {ECO:0000313|EMBL:ACV96210.1};
OS   Vibrio cholerae Ban5.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=663915 {ECO:0000313|EMBL:ACV96210.1};
RN   [1] {ECO:0000313|EMBL:ACV96210.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Ban5 {ECO:0000313|EMBL:ACV96210.1};
RX   PubMed=20041216; DOI=10.1371/journal.pgen.1000786;
RA   Wozniak R.A., Fouts D.E., Spagnoletti M., Colombo M.M., Ceccarelli D.,
RA   Garriss G., Dery C., Burrus V., Waldor M.K.;
RT   "Comparative ICE genomics: insights into the evolution of the SXT/R391
RT   family of ICEs.";
RL   PLoS Genet. 5:E1000786-E1000786(2009).
RN   [2] {ECO:0000313|EMBL:ACV96210.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Ban5 {ECO:0000313|EMBL:ACV96210.1};
RA   Fouts D., Durkin S., Wozniak R., Waldor M.;
RT   "Vibrio cholerae ICEVchBan5.";
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR   EMBL; GQ463140; ACV96210.1; -; Genomic_DNA.
DR   AlphaFoldDB; C9E4P5; -.
DR   REBASE; 27566; VchBan5ORFAP.
DR   PATRIC; fig|663915.4.peg.36; -.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR047939; BREX_1_PglX.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR046816; MmeI_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; NF033452; BREX_1_MTaseX; 1.
DR   PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   Pfam; PF20473; MmeI_Mtase; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          275..355
FT                   /note="MmeI-like DNA-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF20473"
FT   DOMAIN          499..630
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   1246 AA;  144140 MW;  A3FFEBBCC8EDC6BE CRC64;
     MKLVDHVDHL RELIEAAFDK QFARLGFSKT KQMDATQVEK LPEEVKTKRE RFAVMLENHI
     GETGGYESAR EKLLDELTFT LFNRLAAIKV MEAASLFPPI LTKQKEHGDR SFGHKAWLEM
     NPHMRDEELE GIRDYLKSAF DELGQTLPLY SKAYPYALLP DAISLNDIID AFNVVDTDAQ
     ANDSSEETIW QSDDVLGWMY ESYNNAKKKA HKDSGDKTEY NKVSLQSQVY TPRWVVQFLV
     ENSLGKMYLE MYPHSEIKQR YKIANAPTTQ IRAPKPLHEV RTIDPACGSG NFLLYAFDFY
     YELYLDQIEN YGADYDEKDI PKLIIENNLH GIDLDDRAIQ LAQLGLFIKA KKKRRTVGEL
     HFKVVSSDFY LPEYVAVKHI FEQGNLVSAQ QREFIEKVWG DLMQAYKFGS LIHIDKELKE
     QLSQVKERAL GETFDSTQKL KKKIVEGDLF AAADYAEHQE FAENFFANLF AAVEQYARTE
     RNTFLSGKTR DAITFLELLT TEYDLATANP PYTDSADFGP DLKEFIEDNY KKPHKFNTNL
     YATFIKRCCE LTDKDGKVAM VHPPTFMYIK TFEDVRKYMI EKTSIDLFVE WGYLGMFHQS
     ARVDAAMYVL DKNKQEKDST FIKLNHIYEG KRYNAFVEAY DNLIDGVAYQ NNYTIPQSKL
     KIIKSWPFIY WISDDFRAKF GEEALGDNNK ALTGLMTGNN NKFLRFFWEV NPANLSDHYP
     SDSKRWVGYQ KGGPFVRWYG NNWCVVDFSS NGEKLATTDN REFYFKEGIS YSASGSKGVS
     FRQIENKYSF DKGGPCVFNI QQKFTNEYLL GFMNAKLCGY IVDCLNPTVN RQVGDIRRIP
     IAIPTKSQDS GISILVKTNV EIKKRLCQFS IVESLYLYSP FIFFTQGEFK FRLSGFYNLE
     NHLITQILLN EAIINEKIFE VYDLTEHDKA MVLAKEGVSI GGLPITLEAR AAYLSETEAT
     KEFPLDAIRE FIEALPLKKF SAEEREAIES GFGSLYQSNN DLEEFCIRHQ VNPINVWYWF
     KQSKVIPKQR MQTLAMEFLA NMIREILMED EDGIIPLVPN AGEKVLLDRI EEKFFEKGFS
     TAQYSSFDSV LGRPIHDYLN KYFFAELSDH LNLFMYLPKT PFIWHLTSGP EQGFDCYIII
     YKWSRDNLLR LRSVYIENRE RALQNRQSDI AGNESAEAQN EKERIFKQLK EIDAFKKKID
     ELLAEGYNPI LDDGVGKNIA PLQKKKMLAY DVLNAGQLKK YLNADW
//