ID C9EFD2_HASV6 Unreviewed; 921 AA.
AC C9EFD2;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Nonstructural protein {ECO:0000313|EMBL:ACV92105.1};
OS Human astrovirus-6 (HAstV-6).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC Stellavirales; Astroviridae; Mamastrovirus; Mamastrovirus 1.
OX NCBI_TaxID=37130 {ECO:0000313|EMBL:ACV92105.1, ECO:0000313|Proteomes:UP000147435};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACV92105.1, ECO:0000313|Proteomes:UP000147435}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=192-BJ07-CHN {ECO:0000313|EMBL:ACV92105.1};
RX PubMed=20137100;
RA Guo L., Gonzalez R., Wang W., Li Y., Paranhos-Baccala G., Vernet G.,
RA Wang J.;
RT "Complete genome sequence of human astrovirus genotype 6.";
RL Virol. J. 7:29-29(2010).
CC -!- FUNCTION: Protein covalently attached to the 5' extremity of the
CC genomic and subgenomic RNAs. {ECO:0000256|ARBA:ARBA00029406}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC Evidence={ECO:0000256|ARBA:ARBA00024586};
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000256|ARBA:ARBA00004301};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004301}.
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DR EMBL; GQ495608; ACV92105.1; -; Genomic_RNA.
DR MEROPS; S01.109; -.
DR Proteomes; UP000147435; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0070008; F:serine-type exopeptidase activity; IEA:InterPro.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR045835; Astro_1A.
DR InterPro; IPR045833; Astro_p19.
DR InterPro; IPR045836; Astro_VPg.
DR InterPro; IPR022068; Mamastrovirus_p20.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR Pfam; PF19415; Astro_1A; 1.
DR Pfam; PF19414; Astro_p19; 1.
DR Pfam; PF19416; Astro_VPg; 1.
DR Pfam; PF12285; Astrovir_pp_1; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 156..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 787..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 899..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 921 AA; 103828 MW; 10959B20B02D5C7F CRC64;
MTLGEPYYSS KPDKDFDFGS TMARRHVTPS MVEKLPKFVR NSPQAYDWIV RGLIFPTTGK
IYFQRVVVVT GGLEDGTYGS FAFDGKEWVE IHPIEHLNLM ASLKLIHKSN ALQERLRHSQ
EEKATLALDV QFLQHENVRL KELIPKSRPR VIQMKWVILG AVLTFLSLIP GGYAHSQQNK
TIFTDMLTAC KYSTETLTEN LDLRIKIALA NITITDKLDA MKQIFNFAFV PRVHWLRTVF
HYIHYYEMWN IFMFVLAVST VMKSTRPGTD LITLATSRLS GFRMAVLPTI PFHTTLTLWV
MDTLMLVYFF DNLLAITRAL LAPILGIVFL CFMEDSNYVN QVRGLIATAI LIAGGHACLT
LTGTTTSLFV VILTCRFIRM ATVFVGARFE IRDANGKVVA TVPTRIRNAA FDFFQKLKQS
GVRVGVNDFV VIKPGALCII DTPEGKGTGF FSGNDIITAA HVVGNNTFVN VCYEGLMYEA
KVRYMPEKDI AFITCPGDLH PTTRLKLAKN PDYSSVTVMA YVNEELVVST ATAMVHGNTL
SYAARTQDGM SGAPVCDKYG RVLAVHQTNT GYTGGAVVID PADFHPVKAP SQIEQLKEEI
ERLKAQLSAT TESAPDTTEP QSIATLEQKN VSDNDVVDLV RIAMEREMKV LRDEINKVLE
PFIQKKKGKT KHGRGRVRRN LRKGVKLLTE EEYRELLEKG LDRETFLDLI DRIIGERAGY
PDYDDDEYYD DDDDGWGLVG DDVEFDYTEV INFDQHRKKP TPAPRIFKPK LAPAPVTEVQ
PLDLSCKQQV QSEPEQQPEP IKTQKNEPQP YSQTYGKAPI WESYDFDWDE DDARYILPAP
HRLTKADEIV LGSKIVKLRT IIETAIKTQN YGALPEAVFE LDKAAYEAGL EGFLQRVKSK
NKAPKNYKGP QKTKGPKTTT H
//
