ID C9EFG2_9NOCA Unreviewed; 413 AA.
AC C9EFG2;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
DE Flags: Fragment;
GN Name=gyrB {ECO:0000313|EMBL:ACV89664.1};
OS Nocardia jiangxiensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=282685 {ECO:0000313|EMBL:ACV89664.1};
RN [1] {ECO:0000313|EMBL:ACV89664.1}
RP NUCLEOTIDE SEQUENCE.
RA Moser B.D., Lasker B.A., Steigerwalt A.G., Hinrikson H.P., Brown J.M.;
RT "Nocardia niwae, sp. nov., isolated from human pulmonary sources.";
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrB family.
CC {ECO:0000256|ARBA:ARBA00010708}.
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DR EMBL; GQ496107; ACV89664.1; -; Genomic_DNA.
DR AlphaFoldDB; C9EFG2; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00822; TopoII_Trans_DNA_gyrase; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR000565; Topo_IIA_B.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR InterPro; IPR018522; TopoIIA_CS.
DR InterPro; IPR006171; TOPRIM_domain.
DR PANTHER; PTHR45866:SF1; DNA GYRASE SUBUNIT B, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR01159; DNAGYRASEB.
DR PRINTS; PR00418; TPI2FAMILY.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR PROSITE; PS00177; TOPOISOMERASE_II; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 340..413
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACV89664.1"
FT NON_TER 413
FT /evidence="ECO:0000313|EMBL:ACV89664.1"
SQ SEQUENCE 413 AA; 45580 MW; 64A5686635648E56 CRC64;
SESYAVSGGL HGVGISVVNA LSTRLQAEID YDGHHWSQEY KDAKPGKLIQ GESTKRTGTT
IRFWADPNIF ETTVFNFETV SRRLQEMAFL NKGLTITLTD ERVTESEVTE EVVSEHAEAP
KHAEEAAPVE HKVKTRTYHY PGGLEDFVKH INRTKQPIHN TVVAFTGKGT GHELEVAMQW
NSGYSESVHT FANTINTHEG GTHEEGFRAA LTTVVNKYAK DKKLLKEKDG NLTGDDIREG
LAAIVSVKVG EPQFEGQTKT KLGNTEVKSF VQRTCNEHLA HWFEANPADA KTIVNKAVSS
AQARVAARKA RELVRRKSAT DLGGLPGKLA DCRSKDPTKS EIYIVEGDSA GGSAKSGRDS
MYQAILPLRG KIINVEKARI DRVLKNNEVQ SIITAFGTGI HDEFDIAKLR YHK
//
