ID C9IY67_HUMAN Unreviewed; 179 AA.
AC C9IY67;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Tripartite motif containing 59 {ECO:0000313|Ensembl:ENSP00000418856.1};
DE Flags: Fragment;
GN Name=TRIM59 {ECO:0000313|Ensembl:ENSP00000418856.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000418856.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000418856.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000418856.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC024221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; C9IY67; -.
DR SMR; C9IY67; -.
DR MassIVE; C9IY67; -.
DR MaxQB; C9IY67; -.
DR PeptideAtlas; C9IY67; -.
DR ProteomicsDB; 7624; -.
DR Antibodypedia; 18518; 197 antibodies from 27 providers.
DR Ensembl; ENST00000496222.1; ENSP00000418856.1; ENSG00000213186.8.
DR UCSC; uc062poz.1; human.
DR HGNC; HGNC:30834; TRIM59.
DR VEuPathDB; HostDB:ENSG00000213186; -.
DR GeneTree; ENSGT00940000160146; -.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000213186; Expressed in oocyte and 156 other cell types or tissues.
DR ExpressionAtlas; C9IY67; baseline and differential.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19790; Bbox2_TRIM59_C-XI; 1.
DR CDD; cd16763; RING-HC_TRIM59_C-V; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24098; OUTER SEGMENT 5; 1.
DR PANTHER; PTHR24098:SF14; TRIPARTITE MOTIF-CONTAINING PROTEIN 59; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 38..88
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 120..162
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT NON_TER 179
FT /evidence="ECO:0000313|Ensembl:ENSP00000418856.1"
SQ SEQUENCE 179 AA; 20720 MW; A8D507A1CAC4DA7E CRC64;
MRRRIRIKDS GGVGEECIQP PNHEINKEMH NFEEELTCPI CYSIFEDPRV LPCSHTFCRN
CLENILQASG NFYIWRPLRI PLKCPNCRSI TEIAPTGIES LPVNFALRAI IEKYQQEDHP
DIVTCPEHYR QPLNVYCLLD KKLVCGHCLT IGQHHGHPID DLQSAYLKEK DTPQKLLEQ
//
