ID C9J609_HUMAN Unreviewed; 184 AA.
AC C9J609;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Rho guanine nucleotide exchange factor 3 {ECO:0000313|Ensembl:ENSP00000417087.1};
DE Flags: Fragment;
GN Name=ARHGEF3 {ECO:0000313|Ensembl:ENSP00000417087.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000417087.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000417087.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2] {ECO:0007829|PubMed:23186163}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=23186163;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [3] {ECO:0000313|Ensembl:ENSP00000417087.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AC097358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC099327; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC099559; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC099781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; C9J609; -.
DR SMR; C9J609; -.
DR MassIVE; C9J609; -.
DR MaxQB; C9J609; -.
DR PeptideAtlas; C9J609; -.
DR ProteomicsDB; 8691; -.
DR Antibodypedia; 31503; 207 antibodies from 24 providers.
DR Ensembl; ENST00000468727.5; ENSP00000417087.1; ENSG00000163947.12.
DR UCSC; uc062kvu.1; human.
DR HGNC; HGNC:683; ARHGEF3.
DR VEuPathDB; HostDB:ENSG00000163947; -.
DR GeneTree; ENSGT00940000158385; -.
DR ChiTaRS; ARHGEF3; human.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000163947; Expressed in renal glomerulus and 194 other cell types or tissues.
DR ExpressionAtlas; C9J609; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR46006:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:C9J609,
KW ECO:0007829|MaxQB:C9J609};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 123..184
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 184
FT /evidence="ECO:0000313|Ensembl:ENSP00000417087.1"
SQ SEQUENCE 184 AA; 21082 MW; EA985C05CE09BBD3 CRC64;
MFPSPKAWNF RGRKRKQSTQ DEDAVSLCSL DISEPSNKRV KPLSRVTSLA NLIPPVKATP
LKRFSQTLQR SISFRSESRP DILAPRPWSR NAAPSSTKRR DSKLWSETFD VCVNQMLTSK
EIKRQEAIFE LSQGEEDLIE DLKLAKKAYH DPMLKLSIMT EQELNQIFGT LDSLIPLHEE
LLSQ
//
