ID C9JZ82_HUMAN Unreviewed; 83 AA.
AC C9JZ82;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 8.
DT 24-JAN-2024, entry version 100.
DE SubName: Full=RAS guanyl releasing protein 2 {ECO:0000313|Ensembl:ENSP00000401314.1};
DE Flags: Fragment;
GN Name=RASGRP2 {ECO:0000313|Ensembl:ENSP00000401314.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000401314.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000401314.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000401314.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AP001462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; C9JZ82; -.
DR SMR; C9JZ82; -.
DR IntAct; C9JZ82; 1.
DR MassIVE; C9JZ82; -.
DR PeptideAtlas; C9JZ82; -.
DR ProteomicsDB; 12365; -.
DR Antibodypedia; 2786; 150 antibodies from 27 providers.
DR Ensembl; ENST00000430645.1; ENSP00000401314.1; ENSG00000068831.19.
DR UCSC; uc058czc.1; human.
DR HGNC; HGNC:9879; RASGRP2.
DR VEuPathDB; HostDB:ENSG00000068831; -.
DR GeneTree; ENSGT00940000160483; -.
DR HOGENOM; CLU_080193_2_0_1; -.
DR OMA; HNFHESS; -.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000068831; Expressed in granulocyte and 177 other cell types or tissues.
DR ExpressionAtlas; C9JZ82; baseline and differential.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 1: Evidence at protein level;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00135};
KW Proteomics identification {ECO:0007829|EPD:C9JZ82,
KW ECO:0007829|MaxQB:C9JZ82};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 4..83
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT NON_TER 83
FT /evidence="ECO:0000313|Ensembl:ENSP00000401314.1"
SQ SEQUENCE 83 AA; 9611 MW; 822D5FBC4A90B1DC CRC64;
MAGTLDLDKG CTVEELLRGC IEAFDDSGKV RDPQLVRMFL MMHPWYIPSS QLAAKLLHIY
QQSRKDNSNS LQVKTCHLVR YWI
//