ID C9KQB2_9FIRM Unreviewed; 490 AA.
AC C9KQB2;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 28-MAR-2018, entry version 55.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN ECO:0000313|EMBL:EEX67903.1};
GN ORFNames=MITSMUL_05427 {ECO:0000313|EMBL:EEX67903.1};
OS Mitsuokella multacida DSM 20544.
OC Bacteria; Firmicutes; Negativicutes; Selenomonadales;
OC Selenomonadaceae; Mitsuokella.
OX NCBI_TaxID=500635 {ECO:0000313|EMBL:EEX67903.1, ECO:0000313|Proteomes:UP000003671};
RN [1] {ECO:0000313|EMBL:EEX67903.1, ECO:0000313|Proteomes:UP000003671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 20544 {ECO:0000313|EMBL:EEX67903.1,
RC ECO:0000313|Proteomes:UP000003671};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B.,
RA Courtney L., Fronick C., Harrison M., Strong C., Farmer C.,
RA Delahaunty K., Markovic C., Hall O., Minx P., Tomlinson C.,
RA Mitreva M., Nelson J., Hou S., Wollam A., Pepin K.H., Johnson M.,
RA Bhonagiri V., Nash W.E., Warren W., Chinwalla A., Mardis E.R.,
RA Wilson R.K.;
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the initiation and regulation
CC of chromosomal replication. Binds to the origin of replication; it
CC binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC ECO:0000256|SAAS:SAAS00747961}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC ECO:0000256|SAAS:SAAS00555179}.
CC -!- CAUTION: The sequence shown here is derived from an
CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC preliminary data. {ECO:0000313|EMBL:EEX67903.1}.
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DR EMBL; ABWK02000023; EEX67903.1; -; Genomic_DNA.
DR RefSeq; WP_005842697.1; NZ_GG697143.2.
DR ProteinModelPortal; C9KQB2; -.
DR STRING; 500635.MITSMUL_05427; -.
DR EnsemblBacteria; EEX67903; EEX67903; MITSMUL_05427.
DR PATRIC; fig|500635.8.peg.2036; -.
DR eggNOG; ENOG4105CI4; Bacteria.
DR eggNOG; COG0593; LUCA.
DR OrthoDB; POG091H02FF; -.
DR Proteomes; UP000003671; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR024633; DnaA_N_dom.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR Pfam; PF11638; DnaA_N; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW Complete proteome {ECO:0000313|Proteomes:UP000003671};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|SAAS:SAAS00747973};
KW DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00748008};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW Reference proteome {ECO:0000313|Proteomes:UP000003671}.
FT DOMAIN 185 313 AAA. {ECO:0000259|SMART:SM00382}.
FT DOMAIN 397 466 Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT NP_BIND 193 200 ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ SEQUENCE 490 AA; 55219 MW; 6ABA532D9D2B9C16 CRC64;
MEQTQLQAVW EQILTKMKET LAESAFKWFK SVKPISLTAT GLVLSAQNDL VKDWITSHYL
TIIEDAVGAV LGSKRKVDFL VLPSVQPEPE PEPAKPEKDA DSTQDTKEAK EAAGHSSRKK
EDPNQGTLFQ EQPPAPVDNG DMHIVAPGDR SSLNPKYTFE TFVTGSSNRF AHAAAMAVAE
SPGKVYNPFF MYGGVGLGKT HLMHAIGNRV LQNHPEMRVL YVSSEQFTNE IIRAIQEGKA
ELFRQKYRTI DVLMVDDIQF LSGKQSTQEE FFNTFNALHV ADKQIILSSD RPPREVQKLE
DRLRSRFEGG LITDIQAPDL ETRIAILKNK ALLDHVDVPN DVLMFIANRI DSNIRELEGA
LTRVVAYASL INKPVTTDVV AEALKDVFPN SHKKEVTLEV IQEIVATYFK IRIEDLHSKK
RTRSIAFPRQ IAMYLCRELT DTSLPQIGNF FGGRDHTTVL HAYDKIAKER EENAKLHKII
KDLIESIQKM
//
