ID C9P1V6_VIBME Unreviewed; 459 AA.
AC C9P1V6;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=VIB_000455 {ECO:0000313|EMBL:EEX38085.1};
OS Vibrio metschnikovii CIP 69.14.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=675813 {ECO:0000313|EMBL:EEX38085.1, ECO:0000313|Proteomes:UP000005604};
RN [1] {ECO:0000313|EMBL:EEX38085.1, ECO:0000313|Proteomes:UP000005604}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP 69.14 {ECO:0000313|EMBL:EEX38085.1,
RC ECO:0000313|Proteomes:UP000005604};
RG Los Alamos National Laboratory (LANL);
RG National Microbial Pathogen Data Resource (NMPDR);
RA Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D.,
RA Brettin T.S., Colwell R.R., Huq A., Grim C.J., Hasan N.A., Bartels D.,
RA Vonstein V.;
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; ACZO01000005; EEX38085.1; -; Genomic_DNA.
DR RefSeq; WP_004394426.1; NZ_ACZO01000005.1.
DR AlphaFoldDB; C9P1V6; -.
DR STRING; 675813.VIB_000455; -.
DR GeneID; 79888882; -.
DR eggNOG; COG5002; Bacteria.
DR Proteomes; UP000005604; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.210; Two-component sensor protein CpxA, periplasmic domain; 1.
DR InterPro; IPR032404; CpxA_peri.
DR InterPro; IPR038515; CpxA_peri_sf.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR45528; SENSOR HISTIDINE KINASE CPXA; 1.
DR PANTHER; PTHR45528:SF12; SENSOR HISTIDINE KINASE CPXA; 1.
DR Pfam; PF16527; CpxA_peri; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EEX38085.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005604};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 187..240
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 248..457
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 270..297
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 459 AA; 52412 MW; 2C837A9A9A8BD210 CRC64;
MRLPKFNSLY GRIFAIFWLT MLLVVIAVLS LPHLDPRKSR DLPSESLQRM LDYQQLLEKR
FIQQNNLSRI ITELESGSNH SSRPRFFVTD QEGNILTTKR HENFQLKALK NFTTSIESVD
KPQQRLYGRY MISGPVSIRL ADQDLLLFMG MRWDQPPPFL LRLFDKPLHL LLSVMLVSTP
LLLWLAWALS QPAQRLALAA QRVARGEFIV DPELEKGTTE FRQAGRSFNR MVQAVNQMIS
GQQRLLSDIS HELRSPLTRL RMANALASRK QGESKELERI DTEAQRLERM IGELLELSRM
QTNSHLSREI QPLSSLWEAL LDDAQFEAEQ MQKQLLLDPI PDQYISGNPQ LLMSALENVV
RNAINYSQDR IQVSFRCVAQ QIIITVEDDG PGVPDSELNE IFRPFYRVST ARDRDSGGTG
LGLAITESAI RQHSGQVSAS RSDLGGLKVQ ITLPIQRDQ
//
