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Database: UniProt
Entry: C9PQH6_9PAST
LinkDB: C9PQH6_9PAST
Original site: C9PQH6_9PAST 
ID   C9PQH6_9PAST            Unreviewed;       640 AA.
AC   C9PQH6;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   24-JAN-2024, entry version 72.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149,
GN   ECO:0000313|EMBL:EEX50098.1};
GN   ORFNames=HMPREF0621_1169 {ECO:0000313|EMBL:EEX50098.1};
OS   Pasteurella dagmatis ATCC 43325.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Pasteurella.
OX   NCBI_TaxID=667128 {ECO:0000313|EMBL:EEX50098.1, ECO:0000313|Proteomes:UP000005519};
RN   [1] {ECO:0000313|EMBL:EEX50098.1, ECO:0000313|Proteomes:UP000005519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43325 {ECO:0000313|EMBL:EEX50098.1,
RC   ECO:0000313|Proteomes:UP000005519};
RA   Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA   Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA   Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA   Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA   Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA   Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA   Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA   Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA   Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA   Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA   Petrosino J., Highlander S., Gibbs R.;
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EEX50098.1}.
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DR   EMBL; ACZR01000013; EEX50098.1; -; Genomic_DNA.
DR   RefSeq; WP_005761919.1; NZ_GG704810.1.
DR   AlphaFoldDB; C9PQH6; -.
DR   STRING; 667128.HMPREF0621_1169; -.
DR   HOGENOM; CLU_004131_5_1_6; -.
DR   OrthoDB; 9763467at2; -.
DR   Proteomes; UP000005519; Unassembled WGS sequence.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd03482; MutL_Trans_MutL; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW   Rule:MF_00149};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW   Rule:MF_00149}.
FT   DOMAIN          212..330
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          471..624
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
SQ   SEQUENCE   640 AA;  72605 MW;  308107669CB4321E CRC64;
     MPIRVLPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIQIDIEQGG SGLIRIRDNG
     VGIPKTELSL ALARHATSKI SCLDDLDCIL SLGFRGEALA SISSVSRLTL TSRTTDQNEA
     WQVYAQGRDM DTTIVPASHP VGTTVEVANL FFNTPARRKF LRTDKTEFAH IDEVIRRIAL
     AKSHIQFILT HNGKTIRHYK SAVNDTQKLK RISAICGEDF VQNALQIEWR HDDLHLSGWV
     ALPHFSRTQN DLNYCYINGR MVRDKVINHA IRQAYSEHLH NDQYPAFVLF LDLNPNDVDV
     NVHPTKHEVR FHQQRLIHDF ICQGISNALA SEQANLTFHD TIQEPAPSWQ VASSIKPNRA
     AAGQNVFATS SNHSYKNNIS SKFTENRPHF AQQWQHLQPT KQELQAYDEL LNTEKTEKPV
     YTHATSLYAK TEEEKSNLIS TNQTTVVNIS VSNVTAQTSP ILFNQNAFLR TLALVENRAL
     LLQQQQHFYL LPVQKLQHLN IKLTLQEPPV LQQPLLIPVI FRLNDKEFAH WQQQQDFFTQ
     VGFEFVENPQ QKRLTLNKVP SCLRQQNLQQ CVLSLLATPS EEFSHFLTAL CQSLQLPEIN
     VFADAVTLLT STEQRLSSKQ TEHLQSLLIP IDWQHYLAQI
//
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