ID C9RDQ0_METVM Unreviewed; 406 AA.
AC C9RDQ0;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Isopropylmalate/citramalate/homocitrate synthase {ECO:0000313|EMBL:ACX73429.1};
GN OrderedLocusNames=Metvu_1576 {ECO:0000313|EMBL:ACX73429.1};
OS Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7)
OS (Methanococcus vulcanius).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanocaldococcaceae; Methanocaldococcus.
OX NCBI_TaxID=579137 {ECO:0000313|EMBL:ACX73429.1, ECO:0000313|Proteomes:UP000002063};
RN [1] {ECO:0000313|EMBL:ACX73429.1, ECO:0000313|Proteomes:UP000002063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700851 / DSM 12094 / M7
RC {ECO:0000313|Proteomes:UP000002063};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Lcollab F.I., Brettin T., Detter J.C.,
RA Han C., Tapia R., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Ovchinikova G., Sieprawska-Lupa M., Whitman W.B., Woyke T.;
RT "Complete sequence of chromosome of Methanocaldococcus vulcanius M7.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the alpha-IPM synthase/homocitrate synthase
CC family. {ECO:0000256|ARBA:ARBA00006154, ECO:0000256|RuleBase:RU003523}.
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DR EMBL; CP001787; ACX73429.1; -; Genomic_DNA.
DR AlphaFoldDB; C9RDQ0; -.
DR STRING; 579137.Metvu_1576; -.
DR KEGG; mvu:Metvu_1576; -.
DR eggNOG; arCOG02092; Archaea.
DR HOGENOM; CLU_022158_4_2_2; -.
DR Proteomes; UP000002063; Chromosome.
DR GO; GO:0046912; F:acyltransferase activity, acyl groups converted into alkyl on transfer; IEA:InterPro.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd07940; DRE_TIM_IPMS; 1.
DR Gene3D; 1.10.238.260; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR002034; AIPM/Hcit_synth_CS.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR011830; LEU1_arch.
DR InterPro; IPR000891; PYR_CT.
DR NCBIfam; TIGR02090; LEU1_arch; 1.
DR PANTHER; PTHR42880:SF2; (R)-CITRAMALATE SYNTHASE CIMA; 1.
DR PANTHER; PTHR42880; HOMOCITRATE SYNTHASE; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS00815; AIPM_HOMOCIT_SYNTH_1; 1.
DR PROSITE; PS00816; AIPM_HOMOCIT_SYNTH_2; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 3: Inferred from homology;
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003523}.
FT DOMAIN 28..281
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
SQ SEQUENCE 406 AA; 45265 MW; 21E0546187508C5F CRC64;
MVMLMDFLFE NSWKAICPYN PKLDLKDIYI YDTTLRDGEQ TPGVCFTKEQ KLEIARKLDE
LGLKQIEAGF PIVSEREADI VKTIANEGLN ADILALCRAL KKDIDKAIEC DVDGIITFIA
TSPLHLKYKF NNKSLDEILE MGVSAVEYAK EHGLFVAFSA EDATRTPIED LIKVHKAAEE
AGADRVHIAD TTGCATPQSM EFICRTLKEN LKKSHIGVHC HNDFGFAVIN SIYGLIGGAK
AVSTTVNGIG ERAGNASLEE LIMALTVLYD VDLELNLEVL PELCRMVEKY SGIKMPKNKP
IVGELVFAHE SGIHVDAVIE NPLTYEPFLP EKIGVKRNIL LGKHSGCRAV AYKLKLMGID
YDKEMLCEIV KKVKEIREEG KFITDEIFRN IVEEVLKNKK NSAQGE
//
