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Database: UniProt
Entry: C9RHL5_METVM
LinkDB: C9RHL5_METVM
Original site: C9RHL5_METVM 
ID   C9RHL5_METVM            Unreviewed;       438 AA.
AC   C9RHL5;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   24-JAN-2024, entry version 68.
DE   RecName: Full=UDP-N-acetyl-D-mannosamine dehydrogenase {ECO:0000256|ARBA:ARBA00016796};
DE            EC=1.1.1.336 {ECO:0000256|ARBA:ARBA00012935};
DE   AltName: Full=UDP-ManNAc 6-dehydrogenase {ECO:0000256|ARBA:ARBA00030172};
GN   OrderedLocusNames=Metvu_1209 {ECO:0000313|EMBL:ACX73067.1};
OS   Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7)
OS   (Methanococcus vulcanius).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=579137 {ECO:0000313|EMBL:ACX73067.1, ECO:0000313|Proteomes:UP000002063};
RN   [1] {ECO:0000313|EMBL:ACX73067.1, ECO:0000313|Proteomes:UP000002063}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700851 / DSM 12094 / M7
RC   {ECO:0000313|Proteomes:UP000002063};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Lcollab F.I., Brettin T., Detter J.C.,
RA   Han C., Tapia R., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Ovchinikova G., Sieprawska-Lupa M., Whitman W.B., Woyke T.;
RT   "Complete sequence of chromosome of Methanocaldococcus vulcanius M7.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2
CC         NADH + UDP-N-acetyl-alpha-D-mannosaminouronate; Xref=Rhea:RHEA:25780,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:68623, ChEBI:CHEBI:70731;
CC         EC=1.1.1.336; Evidence={ECO:0000256|ARBA:ARBA00001205};
CC   -!- SUBUNIT: Homotetramer; probably dimer of dimers.
CC       {ECO:0000256|ARBA:ARBA00034325}.
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR   EMBL; CP001787; ACX73067.1; -; Genomic_DNA.
DR   RefSeq; WP_015733287.1; NC_013407.1.
DR   AlphaFoldDB; C9RHL5; -.
DR   STRING; 579137.Metvu_1209; -.
DR   GeneID; 8513549; -.
DR   KEGG; mvu:Metvu_1209; -.
DR   eggNOG; arCOG00252; Archaea.
DR   HOGENOM; CLU_023810_3_2_2; -.
DR   OMA; GHCLPID; -.
DR   OrthoDB; 372050at2157; -.
DR   Proteomes; UP000002063; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0089714; F:UDP-N-acetyl-D-mannosamine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028359; UDP_ManNAc/GlcNAc_DH.
DR   NCBIfam; TIGR03026; NDP-sugDHase; 1.
DR   PANTHER; PTHR43491; UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43491:SF2; UDP-N-ACETYL-D-MANNOSAMINE DEHYDROGENASE; 1.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500136; UDP_ManNAc_DH; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF52413; UDP-glucose/GDP-mannose dehydrogenase C-terminal domain; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          322..419
FT                   /note="UDP-glucose/GDP-mannose dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00984"
SQ   SEQUENCE   438 AA;  49517 MW;  58A5E3C1E9B06A3A CRC64;
     MGEQIKSENK ENKKICVIGL GYIGLPTASM LAIQGFNVIG VDINKKRVEE IKNLTFKTTE
     KDLMTLVKGA ISSGNLKVQT KPEKADVYII CVPTPCIEID GEKKCDLTYL NEAMKNLRPL
     LEDGNLIIIE STIPPGTTEE IYNLLSENKK IHLAHCPERV LPGNILRELV ENDRVIGGVD
     ETSAKMAKEI YESFVVGKIY LTDAKTAEMV KLMENTYRDV NIALANEFAK IAEEIGIDVW
     EAIKLANQHP RVNILKPGPG VGGHCISIDP WFIIEKSKNA KLIRTARELN DSMPLFVVEK
     IKKILNNMDN KKNNKKEKEI ISIFGITYKG NVDDTRESPA ERVVEELIKE GFEVRCYDKY
     ANEFKYPLYD LDSAIENSDM IVILTDHDEY KSFDKEKLTK IASKMKKKVI LDTKNIIDRN
     LWRDVGFKVY VLGDGKNA
//
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