ID   C9SBK4_VERA1            Unreviewed;       499 AA.
AC   C9SBK4;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=Peptide hydrolase {ECO:0000256|RuleBase:RU361240};
DE            EC=3.4.-.- {ECO:0000256|RuleBase:RU361240};
GN   ORFNames=VDBG_01847 {ECO:0000313|EMBL:EEY15738.1};
OS   Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)
OS   (Verticillium wilt of alfalfa) (Verticillium albo-atrum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=526221 {ECO:0000313|Proteomes:UP000008698};
RN   [1] {ECO:0000313|Proteomes:UP000008698}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VaMs.102 / ATCC MYA-4576 / FGSC 10136
RC   {ECO:0000313|Proteomes:UP000008698};
RX   PubMed=21829347; DOI=10.1371/journal.ppat.1002137;
RA   Klosterman S.J., Subbarao K.V., Kang S., Veronese P., Gold S.E.,
RA   Thomma B.P.H.J., Chen Z., Henrissat B., Lee Y.-H., Park J.,
RA   Garcia-Pedrajas M.D., Barbara D.J., Anchieta A., de Jonge R., Santhanam P.,
RA   Maruthachalam K., Atallah Z., Amyotte S.G., Paz Z., Inderbitzin P.,
RA   Hayes R.J., Heiman D.I., Young S., Zeng Q., Engels R., Galagan J.,
RA   Cuomo C.A., Dobinson K.F., Ma L.-J.;
RT   "Comparative genomics yields insights into niche adaptation of plant
RT   vascular wilt pathogens.";
RL   PLoS Pathog. 7:E1002137-E1002137(2011).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M28 family. M28A subfamily.
CC       {ECO:0000256|ARBA:ARBA00005957}.
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DR   EMBL; DS985215; EEY15738.1; -; Genomic_DNA.
DR   RefSeq; XP_003007659.1; XM_003007613.1.
DR   AlphaFoldDB; C9SBK4; -.
DR   GeneID; 9535284; -.
DR   KEGG; val:VDBG_01847; -.
DR   eggNOG; KOG2195; Eukaryota.
DR   HOGENOM; CLU_024336_0_0_1; -.
DR   OMA; FDMMASP; -.
DR   OrthoDB; 51543at2759; -.
DR   Proteomes; UP000008698; Unassembled WGS sequence.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd03876; M28_SGAP_like; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR045175; M28_fam.
DR   InterPro; IPR041756; M28_SGAP-like.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007484; Peptidase_M28.
DR   PANTHER; PTHR12147; METALLOPEPTIDASE M28 FAMILY MEMBER; 1.
DR   PANTHER; PTHR12147:SF55; PEPTIDE HYDROLASE; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF04389; Peptidase_M28; 1.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW   ECO:0000313|EMBL:EEY15738.1}; Hydrolase {ECO:0000256|RuleBase:RU361240};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU361240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008698};
KW   Zinc {ECO:0000256|RuleBase:RU361240}.
FT   DOMAIN          116..208
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   DOMAIN          236..450
FT                   /note="Peptidase M28"
FT                   /evidence="ECO:0000259|Pfam:PF04389"
SQ   SEQUENCE   499 AA;  53365 MW;  316B3001393374B3 CRC64;
     MPPNSPPMLY ALAKTTLQGK LQNAIKLENL KTHAEAFSDI AYDSEYFRLA GSVGYNRTAD
     YVVENLEALG DYYDVERQTY ADVVEFFNEG AVTIDGEEVE SQTFQFSKNA TLEGLELIWV
     NAYGCNGTQD FPPEIEGNIG LISRGPQGGS CSFALKSANA GAAGAAALVI FDYVPGAPPI
     NGVLSYEDLP EGPTVPTSGI SNELGLALSA RLQDGEEIIV DSFYTATAGD IWYSDNIIAT
     TTRGDPDNIL FVGAHLDSVA EGPGINDNGS GSIAILEVAR QLARYVTNST IRFGWWTAEE
     SGLLGSTYYV ATAEQEELDK VRLYLNFDMV GSGNGILAVY DGDGSAFGLS GPPGSAEAEA
     LFEDYFASQD LPLLPTEFSG RSDYGPFLDV GIPSGGLFTG ADEIKTEEEV ALFGGIAGII
     HDPNYHTQYD TIGNMSYEFL EINTKAIAHA VALYGTSFDG FPERESGGLR TRTTRKVGRL
     GACSSRAINT GHFKACNFA
//