ID C9ZGA0_STRSW Unreviewed; 5514 AA.
AC C9ZGA0;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Putative non-ribosomal peptide synthetase {ECO:0000313|EMBL:CBG67541.1};
GN OrderedLocusNames=SCAB_3321 {ECO:0000313|EMBL:CBG67541.1};
OS Streptomyces scabiei (strain 87.22).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=680198 {ECO:0000313|EMBL:CBG67541.1, ECO:0000313|Proteomes:UP000001444};
RN [1] {ECO:0000313|EMBL:CBG67541.1, ECO:0000313|Proteomes:UP000001444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=87.22 {ECO:0000313|EMBL:CBG67541.1,
RC ECO:0000313|Proteomes:UP000001444};
RX PubMed=20064060; DOI=10.1094/MPMI-23-2-0161;
RA Bignell D.R., Seipke R.F., Huguet-Tapia J.C., Chambers A.H., Parry R.J.,
RA Loria R.;
RT "Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic
RT cluster that contributes to plant-microbe interactions.";
RL Mol. Plant Microbe Interact. 23:161-175(2010).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; FN554889; CBG67541.1; -; Genomic_DNA.
DR STRING; 680198.SCAB_3321; -.
DR KEGG; scb:SCAB_3321; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_223467_0_0_11; -.
DR Proteomes; UP000001444; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd17646; A_NRPS_AB3403-like; 2.
DR CDD; cd19540; LCL_NRPS-like; 3.
DR CDD; cd05235; SDR_e1; 1.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 6.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR010080; Thioester_reductase-like_dom.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR NCBIfam; TIGR01746; Thioester-redct; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 4.
DR Pfam; PF13193; AMP-binding_C; 4.
DR Pfam; PF00668; Condensation; 7.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 5.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 12.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00455; AMP_BINDING; 4.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001444}.
FT DOMAIN 937..1011
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1883..1958
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2903..2978
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3955..4030
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5021..5096
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 185..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5113..5132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5514 AA; 592300 MW; 5C264D870B35B32A CRC64;
MYTCGVYYDV PGPVDRALLA RAVARTVDET EALRVRFHEV GETVRQAVDP SVQGELAYLE
FGGAADPEAA ARAWIDSDLA TPVPVTGERL FRHTLLRLGP DRYWLHFRYH HILLDGYGQV
LHCRRLLEVY TALAAGEQPS PSGFGTLREV LAEEDAYRRS ARRERDGAYW QREFADLPDS
TELGATVIDS GSHSDGSGSD SGSGSGSGSG SDEAAPALAS GATGLAPSLP SATGRLSGTT
AARVRELGGS RWSLPVIAAM VAHTHRVTGA HDVVVRVFMA ARLSPRALAT PAMLVNDVPL
RIRVDSSTTF TALLERVAAR LAEATRHQRY PHDELRRDLA ATAHPGTLSG PSVNVLSFAS
AHLPCGPTEA TARQLASGPV RDLALHAFGD PDADDGIELT VNAHPGRFTP GTAATHRDRY
TRLLAAATEH PELPIGALDL LDDAERERFH ARNDTSRTAD PRSLVELFEA QDPAAEAVAF
EGERLTYGEL NARVNRLAHA LRAQGVGPES RVAVKLPRSL DLIIALWAVL KTGAAHVPVD
TGYPDDRIAY LIADSRAALV LDEDSMRSLG EGESDTDPGV VPRGDGAAYV IHTSGTTGRP
KGTVVTHAGI ANMLAWMQDE YRLTPADRVV HKTPVGFDVS VWEVFWTLTR GATLVVARPD
GHRDPAYLAR LVRDEQVTVI HFVPAMLGPF LDEYVPTASL RMVSCGGEAL PAGLADRFHR
ECGARLHNSY GPTEFSVTAT SHACTPGEPV TIGVPTHNSR AYVLDPALQP VPDGVTGELY
LAGVQLARGY LDRPGATAER FVADPYGPAA GGRMYRTGDL VRRRADGSLE FAGRADDQVK
INGQRVEPAE VEAVLASVPG VTQAVVLVHD SSAGARQLVG YVTGAPEGDP RSHLARRLPA
AMVPVSVFVL PSIPVTPHGK VDRRALPAPA LPSSGRAPST PAERTLHTLA AALLRRPELG
VDDDLFALGA DSIHAIQLVG RARRQGLRLT PQDVFDHPTV ARLATVAETA STASAAFSAP
LAEDDPVGEL PETPMARRLA ERGGSTAGYA QSLLLAAEPG LSYDRLTAAL QRVLDRHDAL
RTHGTRILPV GAVRAEDCLS RAGDEDVAAR REAARRALSP EDGVMVRAVW FASGRLLLVL
HHLVVDGVSW RILLTDLAEA LAGAELSVPG TSLRRRAAPL AAPVDELPLW TDLLSTREPL
LGIRPLDPAQ DVHGTAGSVT VTVPADLTAT VLGALPAAYR ATPDDILLAA LSAAVQRHRG
EGPVLVDLEG HGRDHLPDGM DLSTTVGWFT RIHPVRLGPG TEADARLIKR TKEELRAIPH
GGRGHDMLRD RLTGLAAPQI SFNYLGRLDA TDLGGWRLAD GGAAVELLAD DDLALTHALQ
IDAYVRDGEL TAEWTYPSGV LTETEVRVLA EAWTGALAEL APYTRGGLTV SDVPLVRITQ
EELDRFRGAT DVLPLSPLQE GLLFLALYEP DDPYVGQLVL ETDTAFDPAR MRAAAAALLH
RHPNLRSAFR SRSQGAPVQV VPADVKVPWE ERDEDDLEAF LARDRARGFS VVRPPLLRFT
ALGDRRLVLT HHHLLLDGWS LPLLVRELFT LYGGTALPPA APYRDHLAWL DRQDDESSAA
VWRERLAGLT APTLLARADR TAEGHDVHEL VLPEALTGAL TSTARAHRLT LNTVVQGLWG
LLLSAFTGRD DVVFGATVSG RPPELPGAES MLGLFVNTLP VRVLIDRDET LAALLARLQQ
EQRSLHAHQH ASLAELVRAS GFDTLFDTVV AFENYPMDEG IEAGGLRLAH AHLVERTHYP
VTLSVFPGDR LRLRFSFLSG AFAPTAVPRL AELLSALIDG AAAGLGSPAA EFVEVSEEDR
LLVMGVAAEG SATAPVTPAG GGEPRTPEEQ SLCAIVAEVL GVERVGVDDE FFALGGTSIL
MIRMAHRVRD EFGVDLSLRD LFAAPTVAGV AARLAGLAPQ AKRITAEERP GRVPLSFAQE
RMWFLQRLQG SSGTYNIPLA IRLTGALDRD ALTGALAGLV TRHEALRTVY PEDADGPHQV
VLPPETPYAT AFVQDCAPDL AADAARPFDL TSDVPLRTTL YETGPDSHVL LLVVHHIAAD
GASLRPLAED ITAGYRARTG DTAAGFPELT VQYPDFAIWQ RETLAADLPR QIAYWKQHLD
GLPPEVTFPG DRPRPAVATH RGDHVEFPVA PELYRRMLDL AGRTRTTPFM VLQAAVSLLL
TRLGAGEDIP LGGVIADRPD SVLDDVVGVF INTLVYRMDT SGDPSFEELL VRVRETGLAA
YAHQGVPFER LVEELNPERS RSRHAFFQVM LAWLDLTEAR FDLPEVTADP GPVTSGTAKF
DVHFDCHVHE SGGLLCRLEY ATDLFDRRTA ESFATRFVRV LEGVTADPAQ RLSEVDVLGA
EDRALVLHGW NDTDVRFDGE GAAVALLEAH ALRTPAAEAV RCEGESVTYG EFNARVNRLA
HALRARGVGP ESRVAVMLPR SVDLMVALWA VLKSGAAYVP IDTGYPADRI AYILADSGAR
LLVSDRDADG FERIAPDVEG PEENPGVTAH GDNAAYVIYT SGSTGRPKGT VNTYAGMANR
LWWMQRDHRL APGERVLQST PVSFDVSVWE VFWTLMYGGT LVVARPDGHR DPLYLERLMR
EESVAVVHLS ASMLGAYLAE TRLPDPVRLV VSGDEALPAE LVRRFHEDSG AVLLNAYGPT
EAAVDVTAWA APADTETVLI GAPVANTRAY VLDAALAPVA PGAPGELYVE GVQLARGYLD
RPGLTAERFV ASPYGPPGSR MYRTGDLARW TADGELEYLG RADDQVKLRG FRVELGEIED
AMADHPAVAR AAAAVHGQWL VGYVVPAAPV DVDDLRDRLA ARLPEYMVPA QIVTLDVLPL
TPNGKLDRKA LPAPDLAHTA GRGPRTPQEE ILCGLFAEVL RVPEVSVDDD FFALGGHSLL
VTRLASRIRA ALDTDLDLSV LFEATTVARL ASRLTGDGPR RSGVTARPRR GRLPLSYAQE
RLWFLHRFEG PSPTYNLPVA LRLSGDLDVA ALTTALGDLA QRHEPLRTVF AEDGEGPHQV
ILSSGPSPAV VRAAEEELDG LVADAVRTPF DLTAEPPLRA TLFALGAGEH VLLLVLHHIA
GDGASMAPLA RDLATAYAAR TRDEEPDWSR LPLQYADFAA WQRQALGTAD DPDSALSRQL
DHWRSTLAGL PEQMELPFDR PRPAVPTHRG DTVPFAVEPA VHEALGRLAR EHHTTVFMVV
HAALVTLLHR LGAGDDIVIG SPVANRTDEA LTPLVGFFAN NLVLRTDLTG DPDFAEVLRR
VRAADLAAYA HQDVPFERVV EAVNPARSTA RHPLFQTGLN FGNADQQAAL DLAVDLPGLT
ARVRPVASPA AKFDLSFFLT ELPEGGVNGL LEFATDLFDR GSAARIAERF TRLLTAVTAE
PGRPVREFDV VDADERRLLL TEWNSTAHEV PDRTLTDLIE AQAARTPDAP AVVFGATILS
YAELDARANR LARRLIDLGA GPERYVAVLL PVSEDIPVVL LAALKTGAGY LPLDPAHPAD
RLAFMLADIA PVAVVTTAEL TDNIGSLADI PVVATDDPAI AERPSGPVTG VVRRPEHAAF
VIFTSGSTGR PKAVVVEHRS LVAYLAWATH VYESLRRRVL VHSPVSFDLT ATGMFGPLVS
GGTVELVRWS ASGPDPDAAV TRPDLVKATP SHLHLLGVVP EEYSPGGQLV LGGESLLGDV
LDAWRARHPG VTVLNEYGPT ETTVGCSLFR IEPGDPVPPG VVTIGTPAWN TRMYVLDALL
RPAPVGTAGE LYVAGDLVTR GYHGRPGLTA GRFVASPFGP PGSRMYRTGD LARWTASGRL
EFVSRVDDQV KIRGFRIELG EVEAVLTAQP GIDAAAVVVR EDTPGDKRLV AYVVSEPDRP
ADPSALRAAA ARALPDYMVP AAFVVLETLP LTANGKIARR ALPAPDLTVG VPRTPAAEGV
ERRIAEVFAE VLGIPEAGAD DDFFRLGGHS LLVARLVNRI RTLFGAELSL RDVFEHSTVA
GITALVTASG AGSAQPGPVR RERPDRVPLS AAQRRMWFLD RLDGPAQTYT IPVVLRMTGP
LDQGALRAAF GDLVRRHEVL RTVIAEGPQG PHQVVVGTAP LVAVRSCDQA EFDAGVAEAA
RTPFSLEHHL PVRATLFTDG EREHALLLLL HHIAGDGSSM RTLAGDLSTA YAARLTGRAP
DWAPLPLQYA DYALWERELP ARRLDFWTKE LAGIPDQLEL PTDRARPAVA SHRGGTVPFA
VPAALRERVD ALGRDRGASA FMVLHATLVT LLHRLGAGDD IVIGTPVEGR PDTALEDLVG
LFANTLVLRA DTSGDPTFEE LLDRVRAVDV AAYDHTDVPF EQLVEVLNPE RSRSRHPLFQ
VMLTVNQEPV APTLPGLAVT VGEAPGDHAK FDLSLTLVEN GEGGWSGSVE YASDLFDRAT
AESVATRWLR LLEEVTADPA RPVHTLPLLT PAEHTDVLVR RNDTGRPLPR MSLPEMFEAQ
VARTPDAVAV IGSRTRLTYD EVNRRANRLA RHLVSLGAGP ETVVAVVLPR RPDVLVALLA
VLKSGAAYLP VDPANPRARI DALVADAGAR IVLDERAFPA GSDRLPDDED AFAVGPDRLP
DGEGAFPVPD RLPDSDLGLP VHPHQAAYLI YTSGSTGRPK GVVVEHGSLA AYLGEAVAMY
PAASGESLVH TSLAFDMPVT TLFTPLVTGG RVRFGDLDAD TPSPGLLKVT PSHLRLLESL
PDRVSDAANL VIGGEALDGT MLGAWRARHP EAVVINEYGP TEATVGCVVH RLEPGDALDA
GPVPIGRPLG NARVYVLDGH LQPVPDGVWG ELYLAGAGLA RGYSGRPGQS AERFVADPYG
PPGTRMYRVG DRARWNRAGV LEYAGRVDEQ VKVRGHRIEP GEIEAALTAL DGVARAAVIA
REDRPGDRRL VAYVVPRRRH GAEPGPGDRP LNPHGAVTAR PAGRVALDLD ALRTRLAATL
PAHLVPSAFV EVDEIPLNTN GKLDRRALPA PPDAVAGTGR APRTPVEVRL CALFAEVLDV
PEVSADDDFF ALGGHSLLAV RLAGRIGEAL GARFTLSTLL EAPTPAALAR RLAESGPQAA
SWVPDSEAEL SPSLRFTYGP SPAGPSGAPH TGPYADGPRE ILLTGATGFV GAFLLAELLH
RTSARVHCLV RARTDAEAGE RLTRALRRHG IALGLTPDDL RLNVVRGDLA EVDLGLAPGQ
WAELGERVDT IVHSGAHVHH LSPYTRLKPA NVEGTRTLLW LAAEGRPKAF HHLSTLGVFG
LGQESRLVTE TSPIEGEKHP FGSGYAASKW VADRLVERAF ERGAGGAVHR LGRIWAHTST
GAVSQDDMFS RLLTSSAALG CHPGGPEAAE ALLPVDVLAR AVVELLLAGS APGSDSGLDT
GTGIARVHHL HHPHRVGAGA FMRAYDRMHG TTSEEVPLAV WLRRLRSANE RGRNLPILPY
QASLEEYVRT APDPRRPVLR FENDRTLQRL RDLSVAIPDI DETAISRYWE FVTT
//
