ID   C9ZJU7_TRYB9            Unreviewed;       462 AA.
AC   C9ZJU7;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   13-SEP-2023, entry version 41.
DE   SubName: Full=Adenosine transporter 2, putative {ECO:0000313|EMBL:CBH09657.1};
GN   ORFNames=TbgDal_II4350 {ECO:0000313|EMBL:CBH09657.1};
OS   Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=679716 {ECO:0000313|EMBL:CBH09657.1, ECO:0000313|Proteomes:UP000002316};
RN   [1] {ECO:0000313|Proteomes:UP000002316}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/CI/86/DAL972 {ECO:0000313|Proteomes:UP000002316};
RX   PubMed=20404998; DOI=10.1371/journal.pntd.0000658;
RA   Jackson A.P., Sanders M., Berry A., McQuillan J., Aslett M.A., Quail M.A.,
RA   Chukualim B., Capewell P., MacLeod A., Melville S.E., Gibson W.,
RA   Barry J.D., Berriman M., Hertz-Fowler C.;
RT   "The genome sequence of Trypanosoma brucei gambiense, causative agent of
RT   chronic human african trypanosomiasis.";
RL   PLoS Negl. Trop. Dis. 4:E658-E658(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC       {ECO:0000256|ARBA:ARBA00007965}.
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DR   EMBL; FN554965; CBH09657.1; -; Genomic_DNA.
DR   RefSeq; XP_011771961.1; XM_011773659.1.
DR   AlphaFoldDB; C9ZJU7; -.
DR   GeneID; 23858815; -.
DR   KEGG; tbg:TbgDal_II4350; -.
DR   VEuPathDB; TriTrypDB:Tbg.972.2.4350; -.
DR   OrthoDB; 2939652at2759; -.
DR   Proteomes; UP000002316; Chromosome 2.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR034764; ENT1/ENT2.
DR   InterPro; IPR002259; Eqnu_transpt.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   NCBIfam; TIGR00939; 2a57; 1.
DR   PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR   PANTHER; PTHR10332:SF82; TRANSPORTER 2, PUTATIVE-RELATED; 1.
DR   Pfam; PF01733; Nucleoside_tran; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        12..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        122..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        161..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        307..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        335..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        402..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        432..456
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          241..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        248..262
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   462 AA;  50730 MW;  66A35D4BBBF5052D CRC64;
     MAMLGFESTA EFFVYLTFIF FGMSVMNVTN AIYSNYNFFS EYYKFVKKQE KAEPENESFW
     KHMFTYYNVV VFTMQVVLEA FMLTPLGRRI PISWRLIFGL TIPMVEIIVI LVIPAVGGSE
     NGAIATMMMV AFVGGISKTL CDSSNAALAG PFPTKFYGAI VWGLAISGLM TSFLAIVIQA
     SMDSSFTSKN TQSQIYFGLV MLLQVVACVL LVLLRKNPYA IKYAAEFRYA ARKDGVTGDG
     ADGEFDAKGT GPADENRYPD EKENKNVLNA DIDPDDMKDT DQVEGTTNAQ QMLDASVMVV
     VKRIWPMLVA CFFVFFATLL VFPGVFIAAK TGDTSGWYFT VVVAMFNLGD FLSRLVLQFK
     QLHVSPRMVM IGSFARALLI IPLSLCAAGT VTGVWLPYIV SLLWGLTNGY FGGLSMIYGP
     RTGSLTTAGQ RSLAAICINV ALLMGLFVGA MFALAVKEGL PK
//