ID C9ZLQ1_TRYB9 Unreviewed; 4232 AA.
AC C9ZLQ1;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Cytoplasmic dynein 2 heavy chain 1 {ECO:0000256|ARBA:ARBA00023902};
GN ORFNames=TbgDal_IV310 {ECO:0000313|EMBL:CBH10326.1};
OS Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=679716 {ECO:0000313|EMBL:CBH10326.1, ECO:0000313|Proteomes:UP000002316};
RN [1] {ECO:0000313|Proteomes:UP000002316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/CI/86/DAL972 {ECO:0000313|Proteomes:UP000002316};
RX PubMed=20404998; DOI=10.1371/journal.pntd.0000658;
RA Jackson A.P., Sanders M., Berry A., McQuillan J., Aslett M.A., Quail M.A.,
RA Chukualim B., Capewell P., MacLeod A., Melville S.E., Gibson W.,
RA Barry J.D., Berriman M., Hertz-Fowler C.;
RT "The genome sequence of Trypanosoma brucei gambiense, causative agent of
RT chronic human african trypanosomiasis.";
RL PLoS Negl. Trop. Dis. 4:E658-E658(2010).
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DR EMBL; FN554967; CBH10326.1; -; Genomic_DNA.
DR RefSeq; XP_011772616.1; XM_011774314.1.
DR GeneID; 23859738; -.
DR KEGG; tbg:TbgDal_IV310; -.
DR VEuPathDB; TriTrypDB:Tbg972.4.310; -.
DR OrthoDB; 168388at2759; -.
DR Proteomes; UP000002316; Chromosome 4.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR049400; DYNC2H1_AAA_dom.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR PANTHER; PTHR10676:SF287; HEAVY CHAIN, PUTATIVE-RELATED; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF21264; DYNC2H1_AAA_dom; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1643..1789
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1939..2087
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2251..2399
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 659..686
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2839..2912
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3050..3119
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4232 AA; 480003 MW; CE962D13DCD8C88A CRC64;
MVSAEKDISD VCVDVAGETL KQLGASVSST NRRSDVVELH IAVGSEKCPP IAAALFSGFV
KAACGSEAGT TKVGLTDVNI DARENFTVLR FAEAVRVRDL DFNELPGDSP PITSVVEVTY
MRYLIKHSEL QVFQVSDFPK CLTPRGGQRL DTVVAGYVLF SLQFSEEDDT KVLLYMKSLR
RVLGGMCTSS FAETVLSQAW GNMDSVEPSH VTDMLEDAQM AITDFWNDSD QDTAIRTKVV
FLMKTVGSNL REYFAKKTLD AGGVFSGSKN ITEVALGCCD EWVNMCKRLT TVDWGSSWGT
AFEDVQLITV RDRLSVVVSI RDLVDEIVEL LTAADKLQSL RTETLWETFD SLDIFATTPA
VEQLWTNCLD AFYRRLQPVE HRCASALSDF FGERGNLAPQ TILNEVVKFR QLIRRPAVSK
ELVNERDALL AKLNERLQSI RMEFERRSES VEDDVALDEE DRRCQAGRFM PGVVNNMIWL
RQLRGRTSDM ISMCKSLLND LQNAGEFLRS ANTLMEEIDD YVIETFKQWT MDVEGSKHVL
MLDANAPLMD IAGDGSVRVN YPERLVQLIR EVRIFRSLGF RISTAIQEMV DQGIRFYRNG
VALKQVASTY NSMKENIIPC TQAMLLEPAL AFENIITASG DRKLTWRNTD DAERFIGKLR
RASQALTDAN RRLHKLHREI ESIVIELFSI DLLRLRERWT GKVRLIREKM ETSGFNNMES
WKQFWDMQIY KALEHQYQLG LESLHEVVAE IKADITYDPD TGLATLRPNI DVIRGQYYQR
IKDFITFPLR FRGCGNSDIF GAMPGNNERG IFAVMKHAAQ LFKKVQQELK RFHPLLVIGR
CGKGGNPSLE DIVGHTLKEV QHWEQSVRLL KQKGKEINAE ELFIKCGCIT ICTAGVKGTV
EDHLHKLSQV LHVTLRDSAQ KNLSRIEEYI AEVTTALGAR LTKLEEIGAA NLQHAKLMEK
RPAVEVEFHH LHNKNVLLQS MANKSDFDFR GVKQRWDEVT RRLDAFEREM EKQVDSLKMS
VEDTVSAWMK NLERFSNQWH EVKPKTVDTP NAMKIVTERR EQFKALKAEG EECIQQCKYF
QLDEPDIEEL EDLERDIEEY VQMWDILVKF QEELDVLRAE PWIIMRAKCY RFEDFGRHWE
EQLRTFSSSP ITVHIRTLLD SWMRCLPVLK YLRGDGFTPS HWGEMFSLIG VRGVTQDTLK
FGDVIDQHET LLRREADLKK LHARAQGEAQ IREALDDVRS WGNNAKFTLI PHPDREGVKL
ITEWKDTMSA LSDNQALLMS MKESPYFGIF ANDANKWEER LACLDEYLRN MSQIQRKWVY
LEPIFRRGAL PQEQERFSRI DKEYLQVMKV VAADSRLVSL AGHTEFKDVL YTVLEQLDRC
QRALNQFLEA KRDSFPRFYF ISDDDLLEIL AHSRNPSVIQ SHLKKLFMGV HSVRFDDAKE
HILQINSLEG EVVPIEESVL ITEEVEEWLG RLDLAVKDTL KLHLVRCVDK VNIGAYSSQI
LSTAGLITFT KQTEDAIRDA KSGGLKKHRA NLQAQLRELT TYAGGNSDVV IGLKVKALIM
DLIHNIEVVD ALIDAGIEKD TDWLWRKQLR FYMDYSDSCV LRMVGAEFRY SYEYQGNAPK
LVHTPLTDRC YLTLTQGMQL GYGGNPYGPA GTGKTESVKA LGNAMGRQVL VFNCDEGIDF
KSMGRIFTGL VKCGAWGCFD EFNRLKVDQL SAVSQMIQVI QEAIKNGEPR CHLMGKEINV
DSNAGIFVTL NPAGKRYGGR SKLPDNLKQL FRSVAMSVPD NELITRTILF SEGFENAVDL
ARKTVEVFKL SRDLLSFQTH YDWGLRSMKA VLRLGGTLIH EYLTERACGK VNPSPEEIFE
KESEIIIKSL RVNTLSKLTF DDALLYNNLI ADIFPGAPIK EIDYAELRPA IEESVKELKL
QLVEAQIQKV LQLYEALRQR MGVVLVGPGG SGKSTLLLIL RRALQRLGKV IPQYIMNPKA
LPRTQLLGYM DNDTREWFDG VLTEAARKVV KEETSVLSWI VCDGDIDPEW VESLNSVLDD
NKLLTMPNGV RIQFGDNVNF IFETHSLEFA SPATVSRTGI IYLSEEDVDP KMMVTSWLVE
QPEDVRDKLE RWINDYFYKA IDALLATGKL IVDTTRTGLV ASGLSQLQGC TGKAQFALAL
VYGLGSYLTE EYRKDYAKEI HSMMSERLPD PKNPLDVYYD ESSNCYRTFD VEPCTDLSVE
DLYRDPMVAT VDCQRNVKIL QAWMKPVRPG IYRPFILVGP EGCGKKMLLT NLFGKTPGTR
VTAVNCSAQT EATHVIQKLK QMCQVYNTNQ GRVLRPKEVE RLVLLLKDMN LPKPDKYGTV
QLHSLLQQIV LYNGFYDTDL EWISLERVQI VGSMNPPGSM GRHPVAPRFL AMVSVLAMSY
PSREAMQNIY TEFFNIMIQS GRLQLNLPGK GAVDIARIMT TVYEAVASRY TVNVASHYMF
NPRDVTSWVL NLLNYNPEDV TNAIGYEGRR IFVDRLVTTE ERSKISKVIH DNLIFLVGHK
SGLSEKETTS FVSWMDTSPI GKKKLTPIAN EELKKPAEDF VLGYSREFAD LDVQLIPEVC
VWMARVDRVL SQERGNLLLV GRSGVCAAGI VRLAAYGLRM ELVTLGITRE YSMKQFNAEL
KTIMMKAGVE GQHVVLLLED HNFTVNSSFL ETINSLLASG EVPGLFAQEE LDAMTAPLKE
DALGEGMSAY AYFVDRIARM LHVCVVMDPT NPNYEPQCRS NPALFTRCNV YWVGTWHTDS
FKLIPRLLMR DVFKSIDSRD NKKDFSLTTE IVHVHKEYIN TFSPQHFKGL CLTYESIFKE
KSRMISEGIT RLQTGVSKLD EAQENVDQIA TDVVEKRKLM EVKQKEADDA LQEIKTNMEA
ASDQKKNIQK IRKDLEKEQK AIEERKSVIE ERLSGIQPTL DAALSAVRSI RSEHLSELKS
LKQPPPAVQD VMEAVIITIG GGGGGDTNWA SIRKILAGDI KEQIINFNIA GFTEATRLRV
TQFMQNHENS FKREVIGRAS KAAAPMAEWI KAVLEYSSVL QTMGPMQAEL KEYEVSLASR
SEKKRKYEEK LTKLEERVEG LKRNFGERTA EAERLKDHAE QAERLYACAH DLLAKLTSEH
DRWVSQIKVI RENQVLLPKR CLLAAAFILY LGNATEDGRR TALNVWKERL KDVDNFEFFT
FMRPESMQLH YKSEGLPGDE LSMDNAVIIQ EQVTTPLIID SSGQALSWLV NHLKGKGLSV
EVCSVSEERF VSSLELALRF GKSFILTDVD GIEAFMYPLF RKELRTEGTK RVIQFGDRRT
VDYADGFQLY LVTNSTDLWI PPDVLSYLTP VNFSITQNGL EGQFLGATIQ HEQPELEKEK
LAVLQKEERL KMQLSDLEES LLKDLAESKG SLLDNKTLID SLNEIKTQAA EISVALETSK
KVQEEIDTKR NVYRPFAKTA SEIFFIVKSL KALSHMYQFS FSFFMGIFND TLHHHEEDRT
DIDTKIDALT KTFVRSVVSS VCTSLFKEHR TVFGIHLARS LYPNDCTAAE WDFFLDRAIA
PEAKKSEVRV PTWVLPDSRD LYRSFAVLFE DLTPKLSLHE ADVWLQWMRS SNPEVSYPKF
ISQLSRFQRL LVVKTLRPDR LMAAVRSTAC DMLHVKSYGD NNTLAQLLTR TEANTPILLI
TTTGADPSQE LQAIAHQKVG RDHFHQLAMG GGQAEEAVRL LRVCAESGDW LFLKNLHLVI
PWVTALQKEL NVLKPDSKFR LFLTSEAHDD FPSIFLSQCL KITFEAPPGV QQNLLHTYQD
WESGPYDAKG TLHTQLLFIT ASFHAILQER RSYIPQGWTK AYEMTSADLK SASDIVLQQA
KGETDWRAIR GLMEDAIYGS RLENEYDMRV LREYTDQFFN PNVLSSAKQQ MNLFAKVKVP
ASGKHGDCLK VISELPENDI PFVFSLPPNA DRVVQLSKVR ALTDDLQLLI EARGESSMSR
EQWANKLRPI LQVWEELMRP NPDLLQQTVS IARDASPILG FMGAEMTSSL RLVSIVDESM
KDLGKVLEGQ ALLREDRRAE ASTMIAGEVP AQWDNYYQGS PRILPWLQSL LHRATSIAKL
FELATNGNLL KSSLNISTMF RPHTFLHALR QETAHSLHEP LVALRLVTSI STPPEGKTVP
VCLEGLMLQG AVLDESNVLQ SIEAADEAAL FPMPKTYVGW MTTMPDSVTT VGVPLYTNGT
KEMFLAELHL PCASELAAKA FILAGVALVL EP
//
