ID   C9ZNP6_TRYB9            Unreviewed;       734 AA.
AC   C9ZNP6;
DT   24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   24-NOV-2009, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   ORFNames=TbgDal_V1620 {ECO:0000313|EMBL:CBH11024.1};
OS   Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=679716 {ECO:0000313|EMBL:CBH11024.1, ECO:0000313|Proteomes:UP000002316};
RN   [1] {ECO:0000313|Proteomes:UP000002316}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/CI/86/DAL972 {ECO:0000313|Proteomes:UP000002316};
RX   PubMed=20404998; DOI=10.1371/journal.pntd.0000658;
RA   Jackson A.P., Sanders M., Berry A., McQuillan J., Aslett M.A., Quail M.A.,
RA   Chukualim B., Capewell P., MacLeod A., Melville S.E., Gibson W.,
RA   Barry J.D., Berriman M., Hertz-Fowler C.;
RT   "The genome sequence of Trypanosoma brucei gambiense, causative agent of
RT   chronic human african trypanosomiasis.";
RL   PLoS Negl. Trop. Dis. 4:E658-E658(2010).
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DR   EMBL; FN554968; CBH11024.1; -; Genomic_DNA.
DR   RefSeq; XP_011773311.1; XM_011775009.1.
DR   AlphaFoldDB; C9ZNP6; -.
DR   GeneID; 23861140; -.
DR   KEGG; tbg:TbgDal_V1620; -.
DR   VEuPathDB; TriTrypDB:Tbg972.5.1620; -.
DR   OrthoDB; 5488182at2759; -.
DR   Proteomes; UP000002316; Chromosome 5.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF261; RNA HELICASE; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000313|EMBL:CBH11024.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          51..212
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          238..415
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          695..734
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        695..724
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   734 AA;  82812 MW;  A71D89E9C1D10C74 CRC64;
     MLSKRNREGS RGAMGCGEKN PYTGRVLSSR YHALRGVREK LPIFAAKQKI QRLISRYQTL
     LLVGETGSGK TTQVPQFVLE MNPEHAIACT QPRRVAAISV SERVAEELDV TLGEEVGYCI
     RFDDTSSDRT RLKYLTDGML LREAMGDPML QRYSVIILDE AHERTVHTDI LIGAVKDLLH
     RRPDLRVVVM SATLEERRFQ SYFPEAPLVH VSGRMYDVEV YNSRLPEANY LEASIRTAMQ
     IHLYEGPGDI LIFLTGEDEI EQAVERLRLG IPMAEHTNAD CHKGPVAVLP LYSALPPKEQ
     RKVFQAAPEG TRKIVVATNV AETSLTIDGV VFVIDSGFSK QKVYNPKLRV ESLLVTPISQ
     ASARQRCGRA GRTRPGKCFR LYTAKAFDTL LQQQTYPEIL RCNLGSVILH MKMMGIEDLV
     NFDFVEPPAP ETLMRALELL NYLGAINDDG DMTKFGRRVA DFPLEPEMAA MLLHSPEYGC
     SDDIARICAM MSVQSPFVTP RNDQRGCAMR CRDQFYHPTG DHLALLNVFN AFYEGSNQSG
     SWASENYLNP RVMKQSVSIY RQLIGIMRRL NLSICSTYSA AQWGGAGDGE SDEYANEVRR
     AVLRGYFTKV ALSLPTKNQF LTLKDNVKCL LFPSTFLNRR PKFVVFNELV LTTNTYIRTV
     TSVSDEWLLE VSPLYFDPSE FEGVSRQVFE ELHRRNKRNN AAERDQNKDC LNGHKRRRGG
     DAPDNGDDDD DDSS
//