ID C9ZZG8_TRYB9 Unreviewed; 492 AA.
AC C9ZZG8;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Metacaspase 5, putative {ECO:0000313|EMBL:CBH14817.1};
GN ORFNames=TbgDal_IX8930 {ECO:0000313|EMBL:CBH14817.1};
OS Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=679716 {ECO:0000313|EMBL:CBH14817.1, ECO:0000313|Proteomes:UP000002316};
RN [1] {ECO:0000313|Proteomes:UP000002316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/CI/86/DAL972 {ECO:0000313|Proteomes:UP000002316};
RX PubMed=20404998; DOI=10.1371/journal.pntd.0000658;
RA Jackson A.P., Sanders M., Berry A., McQuillan J., Aslett M.A., Quail M.A.,
RA Chukualim B., Capewell P., MacLeod A., Melville S.E., Gibson W.,
RA Barry J.D., Berriman M., Hertz-Fowler C.;
RT "The genome sequence of Trypanosoma brucei gambiense, causative agent of
RT chronic human african trypanosomiasis.";
RL PLoS Negl. Trop. Dis. 4:E658-E658(2010).
CC -!- SIMILARITY: Belongs to the peptidase C14B family.
CC {ECO:0000256|ARBA:ARBA00009005}.
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DR EMBL; FN554972; CBH14817.1; -; Genomic_DNA.
DR RefSeq; XP_011777083.1; XM_011778781.1.
DR AlphaFoldDB; C9ZZG8; -.
DR MEROPS; C14.043; -.
DR GeneID; 23860956; -.
DR KEGG; tbg:TbgDal_IX8930; -.
DR VEuPathDB; TriTrypDB:Tbg972.9.8930; -.
DR OrthoDB; 1077459at2759; -.
DR Proteomes; UP000002316; Chromosome 9.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.12660; -; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011600; Pept_C14_caspase.
DR PANTHER; PTHR48104:SF30; METACASPASE-1; 1.
DR PANTHER; PTHR48104; METACASPASE-4; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
PE 3: Inferred from homology;
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..492
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003005529"
FT DOMAIN 62..317
FT /note="Peptidase C14 caspase"
FT /evidence="ECO:0000259|Pfam:PF00656"
FT REGION 358..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..471
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 54467 MW; 5B13D4020252DE72 CRC64;
MDAALALLFG QVATAVLPYV VNSIGRVPRP KRVDVKKAMG EAHQCRPVVP YRAPRPYTEG
RVKALFIGIN YTGSSAQLGG CVNDVMHMLQ TLQRIEFPIS ECCILVDDRR FPNFTAMPTR
ENIIKYMAWL VYDVRPGDVL FFHFSGHGAE TKGGRDSNEK MDQCLVPLDY DKAGAILDDD
LFELMIKGLP AGVRMTAVFD CCHSASLLDL PFAFVAGRNV SSNQRHEMRM VRKDNYSRGD
VVMFSGCEDS GTSADVTNTS SFGNGTVAAG GAATQAFTWA LLNTTGYSYI DIFMKTREVL
RQKGYKQVPQ LSSSKPVDLY KQFSLFGPLT MNASLVQHLP QEYVQPWAPH PAYQQPHEAT
LPASVSQPHS QPVMGIPVAS TSNGKSNPGV SDGGRASGEV YPPTQYPSSH PAPQQQAYYQ
PPQQAYYQPP QQAYYQPPQQ AYYQPPQQAY YQPEPHHQPA PPPPPKKENK PARPGYPMSY
CMKFSQGKPG RK
//