ID C9ZZH9_TRYB9 Unreviewed; 360 AA.
AC C9ZZH9;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Leucine-rich repeat protein (LRRP), putative {ECO:0000313|EMBL:CBH14828.1};
GN ORFNames=TbgDal_IX9040 {ECO:0000313|EMBL:CBH14828.1};
OS Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=679716 {ECO:0000313|EMBL:CBH14828.1, ECO:0000313|Proteomes:UP000002316};
RN [1] {ECO:0000313|Proteomes:UP000002316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/CI/86/DAL972 {ECO:0000313|Proteomes:UP000002316};
RX PubMed=20404998; DOI=10.1371/journal.pntd.0000658;
RA Jackson A.P., Sanders M., Berry A., McQuillan J., Aslett M.A., Quail M.A.,
RA Chukualim B., Capewell P., MacLeod A., Melville S.E., Gibson W.,
RA Barry J.D., Berriman M., Hertz-Fowler C.;
RT "The genome sequence of Trypanosoma brucei gambiense, causative agent of
RT chronic human african trypanosomiasis.";
RL PLoS Negl. Trop. Dis. 4:E658-E658(2010).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FN554972; CBH14828.1; -; Genomic_DNA.
DR RefSeq; XP_011777094.1; XM_011778792.1.
DR AlphaFoldDB; C9ZZH9; -.
DR GeneID; 23860969; -.
DR KEGG; tbg:TbgDal_IX9040; -.
DR VEuPathDB; TriTrypDB:Tbg972.9.9040; -.
DR OrthoDB; 24160at2759; -.
DR Proteomes; UP000002316; Chromosome 9.
DR GO; GO:0005929; C:cilium; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001309; Pept_C14_p20.
DR PANTHER; PTHR15454:SF74; CASPASE FAMILY P20 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15454; NISCHARIN RELATED; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS51450; LRR; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 90..139
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT REGION 220..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 264..326
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 233..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 360 AA; 39571 MW; C7BBD2212A8596DA CRC64;
MELTLTRRGI QSFDASTLLH GASDGAFYEG GASKNQRHLA IRTLDLSHNN ITTFIGGNLL
AGLAVLNLSN NSLQTFDVAF LPSSLTSLNL SHNALRGLWG LAAASPKLQE LNISFNTITS
PNLGELPKFL TTLSCQGNLI DSMCPFVGLQ QLHTLDLSSN RVEDPNELPY LKSMRGLRHL
ELRGNPVMCE PKAVPMLLEA LPRLARLDRT PLSQASGNQM FKVHRSRSAR AAEDQSTSKS
ACDTLSNSSA TRRATSRNGQ DMEVRCLEAR VNELLRLLEG SEKSEQQLRY QKKILREQVS
ACAGVIDSQA LELERLGREI NELRGEEVSL KEPVAELEQT FVQTHASLVA HRLNQSTGFA
//
