ID CCNT1_CAEEL Reviewed; 468 AA.
AC P34425; Q8IG21; Q8IG22;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 27-MAR-2024, entry version 150.
DE RecName: Full=Cyclin-T1.1;
GN Name=cit-1.1; ORFNames=F44B9.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Regulatory subunit of the cyclin-dependent kinase pair
CC (CDK9/cyclin T) complex, also called positive transcription elongation
CC factor B (P-TEFb), which is proposed to facilitate the transition from
CC abortive to production elongation by phosphorylating the CTD (carboxy-
CC terminal domain) of the large subunit of RNA polymerase II (RNAP II).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a;
CC IsoId=P34425-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P34425-2; Sequence=VSP_015984;
CC Name=c;
CC IsoId=P34425-3; Sequence=VSP_015983;
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC {ECO:0000305}.
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DR EMBL; FO080400; CCD63445.1; -; Genomic_DNA.
DR EMBL; FO080400; CCD63446.1; -; Genomic_DNA.
DR EMBL; FO080400; CCD63447.1; -; Genomic_DNA.
DR PIR; S44815; S44815.
DR RefSeq; NP_498744.1; NM_066343.4.
DR RefSeq; NP_871656.1; NM_181927.3.
DR RefSeq; NP_871657.1; NM_181928.5.
DR AlphaFoldDB; P34425; -.
DR SMR; P34425; -.
DR BioGRID; 41331; 4.
DR STRING; 6239.F44B9.4a.1; -.
DR iPTMnet; P34425; -.
DR EPD; P34425; -.
DR PaxDb; 6239-F44B9-4a; -.
DR PeptideAtlas; P34425; -.
DR EnsemblMetazoa; F44B9.4a.1; F44B9.4a.1; WBGene00000507. [P34425-1]
DR UCSC; F44B9.4a; c. elegans. [P34425-1]
DR AGR; WB:WBGene00000507; -.
DR WormBase; F44B9.4a; CE00173; WBGene00000507; cit-1.1. [P34425-1]
DR WormBase; F44B9.4b; CE32418; WBGene00000507; cit-1.1. [P34425-2]
DR WormBase; F44B9.4c; CE32419; WBGene00000507; cit-1.1. [P34425-3]
DR eggNOG; KOG0834; Eukaryota.
DR GeneTree; ENSGT00970000196489; -.
DR HOGENOM; CLU_555800_0_0_1; -.
DR InParanoid; P34425; -.
DR OMA; MADEFTQ; -.
DR OrthoDB; 4848076at2759; -.
DR PhylomeDB; P34425; -.
DR Reactome; R-CEL-112382; Formation of RNA Pol II elongation complex.
DR Reactome; R-CEL-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
DR Reactome; R-CEL-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-CEL-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR Reactome; R-CEL-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-CEL-75955; RNA Polymerase II Transcription Elongation.
DR Reactome; R-CEL-9018519; Estrogen-dependent gene expression.
DR PRO; PR:P34425; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000507; Expressed in adult organism and 4 other cell types or tissues.
DR GO; GO:0008024; C:cyclin/CDK positive transcription elongation factor complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IBA:GO_Central.
DR GO; GO:0032786; P:positive regulation of DNA-templated transcription, elongation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd20539; CYCLIN_CCNT_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; CYCLIN; 1.
DR PANTHER; PTHR10026:SF155; CYCLIN-T; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR Pfam; PF21797; CycT2-like_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Alternative splicing; Cyclin; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..468
FT /note="Cyclin-T1.1"
FT /id="PRO_0000080496"
FT REGION 336..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..400
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..285
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_015983"
FT VAR_SEQ 434..468
FT /note="SARTFDVAPMLTPPTAPKLQSADNSDMDLEDGELE -> RYTFH (in
FT isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_015984"
SQ SEQUENCE 468 AA; 53570 MW; 9E0C2B41A050A256 CRC64;
MSVSSRGAAS PAHRTAPTKW LFTKEEMKKT ASIQEGMSRE EELASRQMAA AFIQEMIDGL
NNVKDPKMKI GHTGLCVAHT HMHRFYYLHS FKKYDYRDVG AACVFLAGKS QECPRKLSHV
ISVWRERKDR KQLTTETARN EAAQIIVLLE SMILQTIAFD LNVHLPHIYV LDIMKKVDKK
EHYRPLTSCA YYFATDVIAV TDWSLRYSAA SMSIVIIHLM AAYANVRIER LFADFINEDS
PWYAKFDETM TNEKLREMEV DFLVTYRNSC QFHHASKFNF REHRPMLENP DVRKLDRTRD
ARSHSPMVHH VPDSTVNVRP RAYVPRDELT VERLNKERGV EEERRKRERD RMAGKLDSST
SSEKRARIDP LANNFVSSSS SSNGKLAPPP IPPQLNFPPP PIVSSGYNHK NQINRKNHEN
NHTNSSVSPA FVPSARTFDV APMLTPPTAP KLQSADNSDM DLEDGELE
//
