ID CED2_CAEBR Reviewed; 277 AA.
AC A8XI74;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Cell death abnormality protein 2 {ECO:0000250|UniProtKB:Q9NHC3};
GN Name=ced-2 {ECO:0000312|EMBL:CAP32348.1}; ORFNames=CBG13568;
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1] {ECO:0000312|EMBL:CAP32348.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000312|EMBL:CAP32348.1};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Required for cell migration and engulfment of cell corpses
CC but not for programmed cell death/apoptosis. Also has a role in the
CC migration of the 2 gonadal distal tip cells (DTCs) (By similarity).
CC {ECO:0000250|UniProtKB:Q9NHC3}.
CC -!- SUBUNIT: Interacts with ced-5 (via C-terminus which contains a
CC candidate SH3-binding, proline-rich region). Forms a ternary complex
CC with ced-5 and ced-12. Interacts (via SH-2 domain) with src-1 (when
CC activated and phosphorylated at 'Tyr-416').
CC {ECO:0000250|UniProtKB:Q9NHC3}.
CC -!- SIMILARITY: Belongs to the CRK family. {ECO:0000255}.
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DR EMBL; HE600980; CAP32348.1; -; Genomic_DNA.
DR RefSeq; XP_002635024.1; XM_002634978.1.
DR AlphaFoldDB; A8XI74; -.
DR SMR; A8XI74; -.
DR STRING; 6238.A8XI74; -.
DR EnsemblMetazoa; CBG13568.1; CBG13568.1; WBGene00034318.
DR GeneID; 8577019; -.
DR KEGG; cbr:CBG_13568; -.
DR CTD; 8577019; -.
DR WormBase; CBG13568; CBP03281; WBGene00034318; Cbr-ced-2.
DR eggNOG; KOG4792; Eukaryota.
DR HOGENOM; CLU_060542_0_0_1; -.
DR InParanoid; A8XI74; -.
DR OMA; KMNVNGQ; -.
DR OrthoDB; 2900795at2759; -.
DR Proteomes; UP000008549; Chromosome IV.
DR GO; GO:0044877; F:protein-containing complex binding; ISS:UniProtKB.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0035591; F:signaling adaptor activity; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; ISS:UniProtKB.
DR GO; GO:1902742; P:apoptotic process involved in development; IEA:EnsemblMetazoa.
DR GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR GO; GO:0043652; P:engulfment of apoptotic cell; ISS:UniProtKB.
DR GO; GO:1903356; P:positive regulation of distal tip cell migration; IEA:EnsemblMetazoa.
DR GO; GO:1901076; P:positive regulation of engulfment of apoptotic cell; IEA:EnsemblMetazoa.
DR GO; GO:0007165; P:signal transduction; ISS:UniProtKB.
DR CDD; cd00173; SH2; 1.
DR CDD; cd11767; SH3_Nck_3; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR19969:SF5; ADAPTER MOLECULE CRK; 1.
DR PANTHER; PTHR19969; SH2-SH3 ADAPTOR PROTEIN-RELATED; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 3: Inferred from homology;
KW Phagocytosis; Reference proteome; Repeat; SH2 domain; SH3 domain.
FT CHAIN 1..277
FT /note="Cell death abnormality protein 2"
FT /id="PRO_0000379933"
FT DOMAIN 14..112
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT DOMAIN 113..173
FT /note="SH3 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 214..275
FT /note="SH3 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 179..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 277 AA; 30797 MW; 6FEBCDB7B563AB82 CRC64;
MNMNGFDPFE WRSFYFPGMS REDAHKLLGE PRVSIGTFLM RDSSQPGEYS LSVREADEGN
TVCHYLIVRD VKEDGTAGVK IAEQSFPDIP ALLNHFKMRV LTEASLLSAY KKPIIEVVVG
TFKFTGERET DLPFEQGERL EILSKTNNDW WEARNALGTT GLVPANYVQV QSGEFANERI
SKGTSQSSIG SSGNGAERFS STSTSSENAE AHPTLPTTAK VTFDRVPNAY DPTQLRVKKG
QTVRVLEKMS NGMYRAELDG QIGSVPFTYI RFNTANQ
//
