ID CFA36_MOUSE Reviewed; 343 AA.
AC Q8C6E0; Q9CWQ4;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 128.
DE RecName: Full=Cilia- and flagella-associated protein 36 {ECO:0000312|MGI:MGI:1913994};
DE AltName: Full=Coiled-coil domain-containing protein 104 {ECO:0000312|MGI:MGI:1913994};
GN Name=Cfap36 {ECO:0000312|MGI:MGI:1913994};
GN Synonyms=Ccdc104 {ECO:0000312|MGI:MGI:1913994};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85; SER-147 AND SER-201, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May act as an effector for ARL3. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ARL3. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8C6E0; Q9WUL7: Arl3; NbExp=5; IntAct=EBI-16180842, EBI-6860857;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96G28}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q96G28}. Cell projection, cilium, flagellum
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CFAP36 family. {ECO:0000305}.
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DR EMBL; AK010468; BAB26962.1; -; mRNA.
DR EMBL; AK075858; BAC36009.1; -; mRNA.
DR EMBL; AL935054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX294116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS24493.1; -.
DR RefSeq; NP_080016.1; NM_025740.3.
DR PDB; 4ZI2; X-ray; 2.20 A; C/D=1-133.
DR PDB; 4ZI3; X-ray; 2.00 A; C/D=1-133.
DR PDBsum; 4ZI2; -.
DR PDBsum; 4ZI3; -.
DR AlphaFoldDB; Q8C6E0; -.
DR SMR; Q8C6E0; -.
DR BioGRID; 229767; 2.
DR DIP; DIP-61817N; -.
DR IntAct; Q8C6E0; 2.
DR STRING; 10090.ENSMUSP00000020754; -.
DR GlyGen; Q8C6E0; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q8C6E0; -.
DR PhosphoSitePlus; Q8C6E0; -.
DR SwissPalm; Q8C6E0; -.
DR EPD; Q8C6E0; -.
DR MaxQB; Q8C6E0; -.
DR PaxDb; 10090-ENSMUSP00000020754; -.
DR PeptideAtlas; Q8C6E0; -.
DR ProteomicsDB; 281596; -.
DR Pumba; Q8C6E0; -.
DR Antibodypedia; 2144; 54 antibodies from 15 providers.
DR DNASU; 216618; -.
DR Ensembl; ENSMUST00000020754.10; ENSMUSP00000020754.4; ENSMUSG00000020462.15.
DR GeneID; 216618; -.
DR KEGG; mmu:216618; -.
DR UCSC; uc007igu.1; mouse.
DR AGR; MGI:1913994; -.
DR CTD; 112942; -.
DR MGI; MGI:1913994; Cfap36.
DR VEuPathDB; HostDB:ENSMUSG00000020462; -.
DR eggNOG; KOG4511; Eukaryota.
DR GeneTree; ENSGT00390000012785; -.
DR HOGENOM; CLU_050059_0_0_1; -.
DR InParanoid; Q8C6E0; -.
DR OMA; VMLGSFM; -.
DR OrthoDB; 180864at2759; -.
DR PhylomeDB; Q8C6E0; -.
DR TreeFam; TF315143; -.
DR BioGRID-ORCS; 216618; 3 hits in 76 CRISPR screens.
DR ChiTaRS; Cfap36; mouse.
DR PRO; PR:Q8C6E0; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8C6E0; Protein.
DR Bgee; ENSMUSG00000020462; Expressed in seminiferous tubule of testis and 254 other cell types or tissues.
DR ExpressionAtlas; Q8C6E0; baseline and differential.
DR Genevisible; Q8C6E0; MM.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0097546; C:ciliary base; IDA:UniProtKB.
DR GO; GO:0035869; C:ciliary transition zone; ISO:MGI.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1520.10; ADP-ribosylation factor-like 2-binding protein, domain; 1.
DR InterPro; IPR023379; BART_dom.
DR InterPro; IPR042541; BART_sf.
DR InterPro; IPR038888; CFAP36.
DR PANTHER; PTHR21532:SF0; CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 36; 1.
DR PANTHER; PTHR21532; PHOSPHODIESTERASE HL; 1.
DR Pfam; PF11527; ARL2_Bind_BART; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell projection; Cilium; Coiled coil; Cytoplasm; Flagellum;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..343
FT /note="Cilia- and flagella-associated protein 36"
FT /id="PRO_0000278639"
FT REGION 165..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 147..187
FT /evidence="ECO:0000255"
FT COMPBIAS 165..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 85
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 147
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 201
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 225
FT /note="Q -> H (in Ref. 1; BAB26962)"
FT /evidence="ECO:0000305"
FT HELIX 8..21
FT /evidence="ECO:0007829|PDB:4ZI3"
FT HELIX 23..36
FT /evidence="ECO:0007829|PDB:4ZI3"
FT HELIX 37..39
FT /evidence="ECO:0007829|PDB:4ZI3"
FT STRAND 42..46
FT /evidence="ECO:0007829|PDB:4ZI3"
FT HELIX 48..72
FT /evidence="ECO:0007829|PDB:4ZI3"
FT HELIX 76..84
FT /evidence="ECO:0007829|PDB:4ZI3"
FT HELIX 87..91
FT /evidence="ECO:0007829|PDB:4ZI3"
FT HELIX 94..104
FT /evidence="ECO:0007829|PDB:4ZI3"
FT HELIX 106..128
FT /evidence="ECO:0007829|PDB:4ZI3"
SQ SEQUENCE 343 AA; 39600 MW; D276DEDCB7400271 CRC64;
MAAEEEDEVE WVVESIAGFL RGPDWSIPIL DFVEQKCEVF DDEEESKLTY TEIHQEYKEL
VEKLLESYLK EIGINEDQFQ EACTSPLAKT RTSQAILQPV LAAEDFTIFK AMMVQKNIEM
QLQAIRIIQE RNGVLPDCLT DGADVVSDLE QEEMKILREV LRKSKEEYDQ EEERKRKKQS
SEAKMEELPV YTSEAEKMSN SQGDGEHFVQ PPSEVKVHFA NQSVQPLARK MELLPETSSL
TQKGLKIPGL EHASMEGPIA NLSALGTEEL RQREHYLKQK RDKLLSMRKD TRTKQIQNTE
QKGKPTREAE EMTEKPEMTA EEKQTLLKRR LLAEKLKEEV INK
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