ID   CIAO1_CULQU             Reviewed;         338 AA.
AC   B0XAF3;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   24-JAN-2024, entry version 77.
DE   RecName: Full=Probable cytosolic iron-sulfur protein assembly protein Ciao1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN   Name=Ciao1 {ECO:0000255|HAMAP-Rule:MF_03037}; ORFNames=CPIJ016096;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC       protein assembly machinery. Required for the maturation of
CC       extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC   -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03037}.
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DR   EMBL; DS232580; EDS43650.1; -; Genomic_DNA.
DR   RefSeq; XP_001866625.1; XM_001866590.1.
DR   AlphaFoldDB; B0XAF3; -.
DR   SMR; B0XAF3; -.
DR   STRING; 7176.B0XAF3; -.
DR   EnsemblMetazoa; CPIJ016096-RA; CPIJ016096-PA; CPIJ016096.
DR   EnsemblMetazoa; XM_001866590.2; XP_001866625.1; LOC6049938.
DR   GeneID; 6049938; -.
DR   KEGG; cqu:CpipJ_CPIJ016096; -.
DR   VEuPathDB; VectorBase:CPIJ016096; -.
DR   VEuPathDB; VectorBase:CQUJHB011270; -.
DR   eggNOG; KOG0645; Eukaryota.
DR   HOGENOM; CLU_000288_57_8_1; -.
DR   InParanoid; B0XAF3; -.
DR   OMA; IREIRWS; -.
DR   OrthoDB; 5486866at2759; -.
DR   PhylomeDB; B0XAF3; -.
DR   Proteomes; UP000002320; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   HAMAP; MF_03037; ciao1; 1.
DR   InterPro; IPR028608; CIAO1/Cia1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR19920:SF0; CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED; 1.
DR   PANTHER; PTHR19920; WD40 PROTEIN CIAO1; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..338
FT                   /note="Probable cytosolic iron-sulfur protein assembly
FT                   protein Ciao1"
FT                   /id="PRO_0000382482"
FT   REPEAT          12..51
FT                   /note="WD 1"
FT   REPEAT          58..97
FT                   /note="WD 2"
FT   REPEAT          102..141
FT                   /note="WD 3"
FT   REPEAT          147..186
FT                   /note="WD 4"
FT   REPEAT          193..232
FT                   /note="WD 5"
FT   REPEAT          234..252
FT                   /note="WD 6"
FT   REPEAT          253..291
FT                   /note="WD 7"
FT   REPEAT          302..338
FT                   /note="WD 8"
SQ   SEQUENCE   338 AA;  37451 MW;  8DC3CD909A6D2921 CRC64;
     MGKLTLLQCL SGHRGRVWGA GWHPRDPVLA TCGEDKTIRI WADDGTGRWV PKTVLSDGHT
     RTIRDVAWSP CGRFLASASF DATVAIWDRR SGEFECNATL EGHENEVKSV SWSKSGALLA
     TCSRDKSVWI WEVAQEDEYE CAAVLNTHSQ DVKKVEWHPN EDVLASASYD NTIQLYREDL
     ADSDWSSFDT LASHDSTVWS IAFDASGSRL ASCSDDQTVR IWQEYKPGNE FGVACPDGKT
     PVWKCVCTLS GFHSRAVYDI SWCKKTGLIA TACGDDMVRI FREVAGSPAN EPTFEMVASK
     HAHSQDANTV EWSPTVAGLL VTTSDDGDVK LWKFEDDE
//