ID CNPY3_DANRE Reviewed; 276 AA.
AC A3KNS2; Q2L6K9; Q5XJK4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 03-APR-2013, entry version 36.
DE RecName: Full=Protein canopy homolog 3;
DE AltName: Full=Trinucleotide repeat-containing gene 5 protein;
DE Flags: Precursor;
GN Name=cnpy3; Synonyms=tnrc5;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=16488878; DOI=10.1016/j.cub.2006.01.055;
RA Hirate Y., Okamoto H.;
RT "Canopy1, a novel regulator of FGF signaling around the midbrain-
RT hindbrain boundary in zebrafish.";
RL Curr. Biol. 16:421-427(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo, and Larva;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Toll-like receptor (TLR)-specific co-chaperone for
CC HSP90B1. Required for proper TLR folding and hence controls TLR
CC exit from the endoplasmic reticulum. Consequently, required for
CC immune responses (By similarity).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum (By similarity).
CC -!- DEVELOPMENTAL STAGE: Expressed ubiquitously at 18 hours post-
CC fertilization (hpf).
CC -!- SIMILARITY: Belongs to the canopy family.
CC -!- SIMILARITY: Contains 1 saposin B-type domain.
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DR EMBL; AB201385; BAE78826.1; -; mRNA.
DR EMBL; BC083297; AAH83297.1; -; mRNA.
DR EMBL; BC133981; AAI33982.1; -; mRNA.
DR IPI; IPI00484276; -.
DR RefSeq; NP_001034894.2; NM_001039805.2.
DR UniGene; Dr.151531; -.
DR GeneID; 550136; -.
DR KEGG; dre:550136; -.
DR CTD; 550136; -.
DR ZFIN; ZDB-GENE-050411-12; tnrc5.
DR eggNOG; NOG288841; -.
DR HOGENOM; HOG000030912; -.
DR HOVERGEN; HBG107736; -.
DR InParanoid; Q2L6K9; -.
DR OrthoDB; EOG4J9N0S; -.
DR NextBio; 20879427; -.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR InterPro; IPR021852; DUF3456.
DR Pfam; PF11938; DUF3456; 1.
DR PROSITE; PS50015; SAP_B; FALSE_NEG.
PE 2: Evidence at transcript level;
KW Chaperone; Coiled coil; Complete proteome; Disulfide bond;
KW Endoplasmic reticulum; Immunity; Innate immunity; Reference proteome;
KW Signal.
FT SIGNAL 1 16 Potential.
FT CHAIN 17 276 Protein canopy homolog 3.
FT /FTId=PRO_0000313783.
FT DOMAIN 30 269 Saposin B-type.
FT COILED 137 162 Potential.
FT COMPBIAS 198 240 Lys-rich.
FT DISULFID 32 190 By similarity.
FT DISULFID 35 178 By similarity.
FT DISULFID 88 150 By similarity.
FT CONFLICT 208 208 D -> E (in Ref. 2; AAH83297).
FT CONFLICT 216 216 K -> N (in Ref. 1; BAE78826).
FT CONFLICT 251 251 M -> T (in Ref. 1; BAE78826).
SQ SEQUENCE 276 AA; 31458 MW; 784F91EC2937610A CRC64;
MNVFISVVLF LGSARAASKT GDDEWVHLPN KCEVCKFVSI EMKSAFDETG KTKEVIDTNY
RFLDDKGAPP IKYVKSDIRF IEVTENVCSR IMQYNLHKER DGSNRFAKGM SETFSTLHNL
VNKGVKVVMD IPYELWNETS AEVADLKKQC DVMVEQYEDV IEDWYKGSQE EDLTTYLCEK
HVLKGQDTGC LKETWAGKKG DMAAIAEDKK KKKGKKKKGK DGEDGQKKEK KVKKKKKKSK
ISDSESSKRR MEAAGFTSDE EEIQKKVPLN QPKTEL
//
